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La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW

3 out of 5
4431 Horizon Hill Blvd San Antonio TX
Fully refundableReserve now, pay when you stay
The price is AU$156 per night from 29 Dec to 30 Dec
AU$156
29 Dec - 30 Dec
includes taxes & fees
With a stay at La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW in San Antonio (Medical Center District), you'll be a 4-minute drive from University ...
Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW
San Antonio Marriott Northwest Medical Center

San Antonio Marriott Northwest Medical Center

3.5 out of 5
3233 NW Loop 410 San Antonio TX
Fully refundableReserve now, pay when you stay
The price is AU$194 per night from 2 Jan to 3 Jan
AU$194
2 Jan - 3 Jan 2026
includes taxes & fees
With a stay at San Antonio Marriott Northwest Medical Center in San Antonio (Medical Center District), you'll be within a 10-minute drive of North Star Mall ...
Opens in a new windowSan Antonio Marriott Northwest Medical Center
Courtyard by Marriott Medical Center San Antonio

Courtyard by Marriott Medical Center San Antonio

3 out of 5
8585 Marriott Dr San Antonio TX
Fully refundableReserve now, pay when you stay
The price is AU$157 per night from 7 Jan to 8 Jan
AU$157
7 Jan - 8 Jan 2026
includes taxes & fees
Located in San Antonio (Medical Center District), Courtyard by Marriott Medical Center San Antonio is within a 10-minute drive of North Star Mall and The Rim ...
Opens in a new windowCourtyard by Marriott Medical Center San Antonio
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Hyatt Vacation Club at Wild Oak Ranch, San Antonio

Hyatt Vacation Club at Wild Oak Ranch, San Antonio

3.5 out of 5
9700 West Military Drive San Antonio TX
Fully refundable
The price is AU$187 per night from 11 Jan to 12 Jan
AU$187
11 Jan - 12 Jan 2026
includes taxes & fees
Located in San Antonio (Far West Side), Hyatt Vacation Club at Wild Oak Ranch, San Antonio is within a 10-minute drive of Aquatica San Antonio Waterpark and ...
Opens in a new windowHyatt Vacation Club at Wild Oak Ranch, San Antonio
Hotel Valencia Riverwalk

Hotel Valencia Riverwalk

4.5 out of 5
150 E Houston St San Antonio TX
Fully refundableReserve now, pay when you stay
The price is AU$215 per night from 18 Jan to 19 Jan
AU$215
18 Jan - 19 Jan 2026
includes taxes & fees
With a stay at Hotel Valencia Riverwalk, you'll be centrally located in San Antonio, steps from San Antonio River and River Walk.
Opens in a new windowHotel Valencia Riverwalk
Drury Plaza Hotel San Antonio Riverwalk

Drury Plaza Hotel San Antonio Riverwalk

3 out of 5
105 S Saint Marys Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is AU$211 per night from 4 Jan to 5 Jan
AU$211
4 Jan - 5 Jan 2026
includes taxes & fees
A stay at Drury Plaza Hotel San Antonio Riverwalk places you in the heart of San Antonio, steps from River Walk and San Antonio River.
Opens in a new windowDrury Plaza Hotel San Antonio Riverwalk
Riverwalk Plaza

Riverwalk Plaza

4 out of 5
100 Villita Street San Antonio TX
Fully refundableReserve now, pay when you stay
With a stay at Riverwalk Plaza, you'll be centrally located in San Antonio, steps from San Antonio River and 3 minutes by foot from River Walk.
Opens in a new windowRiverwalk Plaza
Menger Hotel

Menger Hotel

3.5 out of 5
204 Alamo Plaza San Antonio TX
Fully refundableReserve now, pay when you stay
The price is AU$176 per night from 4 Jan to 5 Jan
AU$176
4 Jan - 5 Jan 2026
includes taxes & fees
With a stay at Menger Hotel, you'll be centrally located in San Antonio, steps from Alamo and Ripley's Believe It or Not!.
Opens in a new windowMenger Hotel
La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

La Quinta Inn & Suites by Wyndham San Antonio Riverwalk

3 out of 5
303 Blum Street San Antonio TX
Fully refundableReserve now, pay when you stay
The price is AU$151 per night from 4 Jan to 5 Jan
AU$151
4 Jan - 5 Jan 2026
includes taxes & fees
With a stay at La Quinta Inn & Suites by Wyndham San Antonio Riverwalk, you'll be centrally located in San Antonio, steps from Shops at Rivercenter and within ...
Opens in a new windowLa Quinta Inn & Suites by Wyndham San Antonio Riverwalk
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Medical Center District Hotels

Haven’t you been dying to check out that swanky new coffee shop? What about the recently opened bar serving drinks in mason jars? And let’s not forget about the barber shops willing to give you a shaved-on-the-sides, long-on-top cut whenever you want. Don’t worry; we’ll help you find the best deals at hotels in Medical Center District.

This hip new ’hood will charm the-you-know-what off you. Medical Center District hotels are comfortable and affordable, and many offer amenities like room service for those late-night meals, as well as a pool to swim in. Some of these hotels will also have you near great shopping such as souvenir shops, clothing boutiques and everything in between. Don’t feel like leaving the hotel for dinner and drinks? Hang out in the lobby bar and meet some of your fellow travellers—you never what kinds of stories they have in their memory log.

There’s no point in going somewhere if you’re not going to stay where all the action is. lastminute.com.au gets you the best offers on where to stay in Medical Center District so you don’t have to waste endless hours searching online. The trip of a lifetime is at your fingertips. Click and go!

Medical Center District hotels essential information

Accommodation
4,720 hotels
Lowest Price
AU$151
Highest Price
AU$215
Popular hotels
La Quinta Inn & Suites by Wyndham San Antonio Medical Ctr NW, San Antonio Marriott Northwest Medical Center, Courtyard by Marriott Medical Center San Antonio, Hotel Valencia Riverwalk, Riverwalk Plaza, La Quinta Inn & Suites by Wyndham San Antonio Riverwalk, Hyatt Vacation Club at Wild Oak Ranch, San Antonio, Menger Hotel, Drury Plaza Hotel San Antonio Riverwalk

Most recent Medical Center District hotel reviews