Book Holiday Homes in Key Largo

Start date: Check-in selected.
To Date
End date: Check-out

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in Key Largo

New Tiny Home- Paddle Boards, Kayaks, Pool, Marina

New Tiny Home- Paddle Boards, Kayaks, Pool, Marina

Key Largo FL
With a stay at this vacation home in Key Largo, you'll be within a 10-minute drive of John Pennekamp Coral Reef State Park and Jimmy Johnson's Big Chill.
Opens in a new windowNew Tiny Home- Paddle Boards, Kayaks, Pool, Marina
BEACHFRONT POOL HOME

BEACHFRONT POOL HOME

Key Largo FL
With a stay at this vacation home in Key Largo (Silver Shores), you'll be within a 15-minute drive of John Pennekamp Coral Reef State Park and Florida Keys National ...
Opens in a new windowBEACHFRONT POOL HOME
Completely Remodeled 3/3 in the heart of Key Largo (Oceanside)

Completely Remodeled 3/3 in the heart of Key Largo (Oceanside)

Key Largo FL
With a stay at this vacation home in Key Largo, you'll be within a 10-minute drive of John Pennekamp Coral Reef State Park and Jacob's Aquatic Center.
Opens in a new windowCompletely Remodeled 3/3 in the heart of Key Largo (Oceanside)
Save an average of 15% on thousands of hotels when you're signed in
Mariners Club Townhouse, Epic Amenities, Tennis & Indoor Pickleball

Mariners Club Townhouse, Epic Amenities, Tennis & Indoor Pickleball

Key Largo FL
With a stay at this vacation home in Key Largo (Rock Harbor), you'll be within a 15-minute drive of John Pennekamp Coral Reef State Park and Bluefin Rock Harbor ...
Opens in a new windowMariners Club Townhouse, Epic Amenities, Tennis & Indoor Pickleball
Marina Villa Mariner`s Club 212

Marina Villa Mariner`s Club 212

Key Largo FL
With a stay at this vacation home in Key Largo (Rock Harbor), you'll be within a 15-minute drive of John Pennekamp Coral Reef State Park and Bluefin Rock Harbor ...
Opens in a new windowMarina Villa Mariner`s Club 212
Fun For All! Key Largo 3/3 Townhome Oceanside Resort

Fun For All! Key Largo 3/3 Townhome Oceanside Resort

Key Largo FL
With a stay at this vacation home in Key Largo, you'll be on the waterfront, within a 10-minute drive of John Pennekamp Coral Reef State Park and Jimmy Johnson's ...
Opens in a new windowFun For All! Key Largo 3/3 Townhome Oceanside Resort
Beautiful Oceanside Mariner's 3 Bedroom Townhome

Beautiful Oceanside Mariner's 3 Bedroom Townhome

Key Largo FL
With a stay at this vacation home in Key Largo (Rock Harbor), you'll be within a 15-minute drive of John Pennekamp Coral Reef State Park and Bluefin Rock Harbor ...
Opens in a new windowBeautiful Oceanside Mariner's 3 Bedroom Townhome
Key Largo home with new hot tub!

Key Largo home with new hot tub!

Key Largo FL
With a stay at this vacation home in Key Largo, you'll be by the sea, within a 10-minute drive of John Pennekamp Coral Reef State Park and Jimmy Johnson's Big ...
Opens in a new windowKey Largo home with new hot tub!
BRAND NEW! KEYS BEACH RETREAT! CAPTIVATING WATERVIEW VILLA! WIFI! FREE GOLF CART

BRAND NEW! KEYS BEACH RETREAT! CAPTIVATING WATERVIEW VILLA! WIFI! FREE GOLF CART

Key Largo FL
With a stay at this vacation home in Key Largo, you'll be on the beach, within a 10-minute drive of John Pennekamp Coral Reef State Park and Jacob's Aquatic ...
Opens in a new windowBRAND NEW! KEYS BEACH RETREAT! CAPTIVATING WATERVIEW VILLA! WIFI! FREE GOLF CART
Don't see what you're looking for?
See all available properties in Key Largo
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Key Largo Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Key Largo vacation homes are the perfect way for you to wing it.

Holiday houses in Key Largo let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Key Largo in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Key Largo adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Key Largo with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Key Largo vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Key Largo Holiday Homes essential information

Accommodation
665 Holiday Homes
Lowest Price
AU$228
Highest Price
AU$763
Popular accommodation
New Tiny Home- Paddle Boards, Kayaks, Pool, Marina, BEACHFRONT POOL HOME, Completely Remodeled 3/3 in the heart of Key Largo (Oceanside), Mariners Club Townhouse, Epic Amenities, Tennis & Indoor Pickleball, Marina Villa Mariner`s Club 212, Fun For All! Key Largo 3/3 Townhome Oceanside Resort, Beautiful Oceanside Mariner's 3 Bedroom Townhome, Key Largo home with new hot tub!, BRAND NEW! KEYS BEACH RETREAT! CAPTIVATING WATERVIEW VILLA! WIFI! FREE GOLF CART

Top trending hotels in Key Largo

Reefhouse Resort & Marina

Reefhouse Resort & Marina

3.5 out of 5
103800 Overseas Hwy Key Largo FL
The price is AU$449 per night from 21 Dec to 22 Dec
AU$449
21 Dec - 22 Dec
includes taxes & fees
With a stay at Reefhouse Resort & Marina in Key Largo, you'll be on the waterfront, within a 5-minute drive of John Pennekamp Coral Reef State Park and Caribbean ...
Opens in a new windowReefhouse Resort & Marina
Marina Del Mar Resort and Marina

Marina Del Mar Resort and Marina

2.5 out of 5
527 Caribbean Drive Key Largo FL
Fully refundableReserve now, pay when you stay
The price is AU$228 per night from 21 Dec to 22 Dec
AU$228
21 Dec - 22 Dec
includes taxes & fees
With a stay at Marina Del Mar Resort and Marina in Key Largo, you'll be on the waterfront, within a 10-minute drive of John Pennekamp Coral Reef State Park and ...
Opens in a new windowMarina Del Mar Resort and Marina
Baker's Cay Resort Key Largo, Curio Collection by Hilton

Baker's Cay Resort Key Largo, Curio Collection by Hilton

4 out of 5
97000 Overseas Hwy Key Largo FL
The price is AU$763 per night from 5 Jan to 6 Jan
AU$763
5 Jan - 6 Jan 2026
includes taxes & fees
With a stay at Baker's Cay Resort Key Largo, Curio Collection by Hilton in Key Largo, you'll be on the waterfront, within a 15-minute drive of John Pennekamp ...
Opens in a new windowBaker's Cay Resort Key Largo, Curio Collection by Hilton
Save an average of 15% on thousands of hotels when you're signed in
The Pelican Key Largo Cottages

The Pelican Key Largo Cottages

2 out of 5
99340 Overseas Highway Key Largo FL
Fully refundableReserve now, pay when you stay
The price is AU$249 per night from 7 Jan to 8 Jan
AU$249
7 Jan - 8 Jan 2026
includes taxes & fees
Located in Key Largo, The Pelican Key Largo Cottages is on the waterfront, within a 15-minute drive of John Pennekamp Coral Reef State Park and Florida Keys ...
Opens in a new windowThe Pelican Key Largo Cottages
Don't see what you're looking for?
See all available properties in Key Largo
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.