Book Holiday Homes in Los Osos

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Featured Holiday Homes in Los Osos

Escape to a Coastal Retreat: Modern 5-Star Beachfront Home w/ 360 Ocean Views!

Escape to a Coastal Retreat: Modern 5-Star Beachfront Home w/ 360 Ocean Views!

Oceano CA
With a stay at this vacation home in Oceano, you'll be near the beach, within a 10-minute drive of Pismo Beach Pier and Pismo State Beach.
Opens in a new windowEscape to a Coastal Retreat: Modern 5-Star Beachfront Home w/ 360 Ocean Views!
LUXURY : VISTA HOUSE above the Clouds! Stunning view near Avila Beach & Downtown

LUXURY : VISTA HOUSE above the Clouds! Stunning view near Avila Beach & Downtown

San Luis Obispo CA
The price is AU$616 per night from 4 Jan to 5 Jan
AU$616
4 Jan - 5 Jan 2026
includes taxes & fees
When you stay at this vacation home in San Luis Obispo, you'll be near the beach and 14 minutes by car from Montaña de Oro State Park.
Opens in a new windowLUXURY : VISTA HOUSE above the Clouds! Stunning view near Avila Beach & Downtown
WALK to Beach, Pier and Downtown - Parking - BBQ - View

WALK to Beach, Pier and Downtown - Parking - BBQ - View

Pismo Beach CA
With a stay at this vacation home, you'll be centrally located in Pismo Beach, a 2-minute drive from Pismo Beach Pier and 15 minutes from California Polytechnic ...
Opens in a new windowWALK to Beach, Pier and Downtown - Parking - BBQ - View
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Breathtaking Ocean and Beach Views

Breathtaking Ocean and Beach Views

Avila Beach California
With a stay at this vacation home, you'll be centrally located in Avila Beach, within a 15-minute drive of Pismo Beach Pier and California Polytechnic State ...
Opens in a new windowBreathtaking Ocean and Beach Views
MOUNTAIN TOP GETAWAY : Best View In SLO! : Pets welcome

MOUNTAIN TOP GETAWAY : Best View In SLO! : Pets welcome

San Luis Obispo CA
The price is AU$616 per night from 3 Jan to 4 Jan
AU$616
3 Jan - 4 Jan 2026
includes taxes & fees
When you stay at this vacation home in San Luis Obispo, you'll be near the beach and 14 minutes by car from Montaña de Oro State Park.
Opens in a new windowMOUNTAIN TOP GETAWAY : Best View In SLO! : Pets welcome
Oceanfront Cayucos Cottage on the sand

Oceanfront Cayucos Cottage on the sand

Cayucos CA
When you a stay at this vacation home in Cayucos, you'll be on the beach, just steps from Morro Strand State Beach and Estero Bay.
Opens in a new windowOceanfront Cayucos Cottage on the sand
Pet Friendly Comfy Morro Bay Home

Pet Friendly Comfy Morro Bay Home

Morro Bay CA
The price is AU$859 per night from 5 Jan to 6 Jan
AU$859
5 Jan - 6 Jan 2026
includes taxes & fees
With a stay at this vacation home in Morro Bay, you'll be by the sea, within a 15-minute drive of California Polytechnic State University, San Luis Obispo and ...
Opens in a new windowPet Friendly Comfy Morro Bay Home
BEACHFRONT with Spa

BEACHFRONT with Spa

Oceano, CA
With a stay at this vacation home in Oceano, you'll be on the beach, within a 10-minute drive of Pismo Beach Pier and Pismo State Beach.
Opens in a new windowBEACHFRONT with Spa
Cottage By The Sea And Trails.  Blocks from the Fiscalini Preserve.

Cottage By The Sea And Trails. Blocks from the Fiscalini Preserve.

Cambria CA
With a stay at this vacation home in Cambria, you'll be a 4-minute walk from Fiscalini Ranch Preserve and within a 5-minute drive of Cambria State Marine ...
Opens in a new windowCottage By The Sea And Trails. Blocks from the Fiscalini Preserve.
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Los Osos Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Los Osos vacation homes are the perfect way for you to wing it.

Holiday houses in Los Osos let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Los Osos in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Los Osos adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Los Osos with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Los Osos vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Los Osos Holiday Homes essential information

Accommodation
793 Holiday Homes
Lowest Price
AU$192
Highest Price
AU$859
Popular accommodation
Escape to a Coastal Retreat: Modern 5-Star Beachfront Home w/ 360 Ocean Views!, LUXURY : VISTA HOUSE above the Clouds! Stunning view near Avila Beach & Downtown, WALK to Beach, Pier and Downtown - Parking - BBQ - View, Breathtaking Ocean and Beach Views, MOUNTAIN TOP GETAWAY : Best View In SLO! : Pets welcome, Oceanfront Cayucos Cottage on the sand, Pet Friendly Comfy Morro Bay Home, BEACHFRONT with Spa , Cottage By The Sea And Trails. Blocks from the Fiscalini Preserve.

Top trending hotels in Los Osos

Back Bay Inn

Back Bay Inn

3.5 out of 5
1391 Second Street Los Osos CA
Fully refundableReserve now, pay when you stay
Located in Los Osos (Baywood Park), Back Bay Inn is within a 10-minute walk of Morro Bay State Park and Morro Coast Audubon Society Sweet Springs Nature ...
Opens in a new windowBack Bay Inn
Sea Pines Resort

Sea Pines Resort

3 out of 5
1945 Solano Street Los Osos CA
Fully refundableReserve now, pay when you stay
When you stay at Sea Pines Resort in Los Osos, you'll be near the beach, within a 5-minute drive of Montaña de Oro State Park and Morro Bay State Park.
Opens in a new windowSea Pines Resort
Quality Suites Downtown San Luis Obispo

Quality Suites Downtown San Luis Obispo

3 out of 5
1631 Monterey St San Luis Obispo CA
Fully refundableReserve now, pay when you stay
The price is AU$241 per night from 4 Jan to 5 Jan
AU$241
4 Jan - 5 Jan 2026
includes taxes & fees
With a stay at Quality Suites Downtown San Luis Obispo in San Luis Obispo, you'll be within a 15-minute walk of California Polytechnic State University, San ...
Opens in a new windowQuality Suites Downtown San Luis Obispo
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La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown

La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown

3 out of 5
1845 Monterey St. San Luis Obispo CA
Fully refundableReserve now, pay when you stay
The price is AU$192 per night from 25 Jan to 26 Jan
AU$192
25 Jan - 26 Jan 2026
includes taxes & fees
With a stay at La Quinta Inn & Suites by Wyndham San Luis Obispo Downtown, you'll be centrally located in San Luis Obispo, within a 5-minute drive of California ...
Opens in a new windowLa Quinta Inn & Suites by Wyndham San Luis Obispo Downtown
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See all available properties in Los Osos
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Subject to availability and chosen travel dates.