Find Downtown Clayton hotels

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Downtown Clayton

Top trending hotels in Downtown Clayton

Clayton Plaza Hotel & Extended Stay

Clayton Plaza Hotel & Extended Stay

3.5 out of 5
7750 Carondelet Avenue, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is AU$189 per night from 18 May to 19 May
AU$189
includes taxes & fees
18 May - 19 May
With a stay at Clayton Plaza Hotel & Extended Stay in St. Louis (Clayton), you'll be within a 5-minute drive of Washington University in St. Louis and Forest ...
Clayton Plaza Hotel & Extended Stay
Le Méridien St. Louis Clayton

Le Méridien St. Louis Clayton

4 out of 5
7730 Bonhomme Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is AU$291 per night from 31 May to 1 Jun
AU$291
includes taxes & fees
31 May - 1 June
Located in St. Louis (Clayton), Le Méridien St. Louis Clayton is within a 5-minute drive of Washington University in St. Louis and Forest Park.
Le Méridien St. Louis Clayton
AC Hotel St. Louis Clayton

AC Hotel St. Louis Clayton

3 out of 5
227 South Central Ave, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is AU$244 per night from 26 May to 27 May
AU$244
includes taxes & fees
26 May - 27 May
With a stay at AC Hotel St. Louis Clayton in St. Louis (Clayton), you'll be a 4-minute drive from Washington University in St. Louis and 7 minutes from St. Louis ...
AC Hotel St. Louis Clayton
Save an average of 15% on thousands of hotels when you're signed in
Pear Tree Inn St. Louis Airport

Pear Tree Inn St. Louis Airport

2.5 out of 5
10810 Pear Tree Ln, St. Ann, MO
Fully refundableReserve now, pay when you stay
The price is AU$173 per night from 11 May to 12 May
AU$173
includes taxes & fees
11 May - 12 May
With a stay at Pear Tree Inn St. Louis Airport, you'll be centrally located in St. Ann, within a 15-minute drive of Hollywood Casino Amphitheatre and Westport ...
Pear Tree Inn St. Louis Airport
Drury Inn & Suites St. Louis Union Station

Drury Inn & Suites St. Louis Union Station

3 out of 5
201 S 20th St, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is AU$205 per night from 11 May to 12 May
AU$205
includes taxes & fees
11 May - 12 May
With a stay at Drury Inn & Suites St. Louis Union Station, you'll be centrally located in St. Louis, just a 5-minute walk from St. Louis Union Station and 11 ...
Drury Inn & Suites St. Louis Union Station
Drury Plaza Hotel St. Louis at the Arch

Drury Plaza Hotel St. Louis at the Arch

3 out of 5
2 South 4th Street, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is AU$218 per night from 14 May to 15 May
AU$218
includes taxes & fees
14 May - 15 May
With a stay at Drury Plaza Hotel St. Louis at the Arch, you'll be centrally located in St. Louis, just a 5-minute walk from Gateway Arch and 6 minutes by foot ...
Drury Plaza Hotel St. Louis at the Arch
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is AU$200 per night from 1 Jun to 2 Jun
AU$200
includes taxes & fees
1 June - 2 June
A stay at Hyatt Regency St. Louis at The Arch places you in the heart of St. Louis, within a 10-minute walk of Gateway Arch and Busch Stadium.
Hyatt Regency St. Louis at The Arch
River City Casino & Hotel

River City Casino & Hotel

4 out of 5
777 River City Casino Blvd, St. Louis, MO
Fully refundableReserve now, pay when you stay
The price is AU$211 per night from 7 May to 8 May
AU$211
includes taxes & fees
7 May - 8 May
When you stay at River City Casino & Hotel in St. Louis, you'll be on the riverwalk, within a 15-minute drive of St. Louis Union Station and Gateway Arch.
River City Casino & Hotel
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive, Maryland Heights, MO
Fully refundableReserve now, pay when you stay
The price is AU$202 per night from 6 May to 7 May
AU$202
includes taxes & fees
6 May - 7 May
Located in Maryland Heights, Hollywood Casino & Hotel St. Louis is on a river, just a 3-minute walk from Hollywood Casino and a 4-minute drive from Hollywood ...
Hollywood Casino & Hotel St. Louis
Don't see what you're looking for?
See all available properties in Downtown Clayton
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Downtown Clayton Hotels

Haven’t you been dying to check out that swanky new coffee shop? What about the recently opened bar serving drinks in mason jars? And let’s not forget about the barber shops willing to give you a shaved-on-the-sides, long-on-top cut whenever you want. Don’t worry; we’ll help you find the best deals at hotels in Downtown Clayton.

This hip new ’hood will charm the-you-know-what off you. Downtown Clayton hotels are comfortable and affordable, and many offer amenities like room service for those late-night meals, as well as a pool to swim in. Some of these hotels will also have you near great shopping such as souvenir shops, clothing boutiques and everything in between. Don’t feel like leaving the hotel for dinner and drinks? Hang out in the lobby bar and meet some of your fellow travellers—you never what kinds of stories they have in their memory log.

There’s no point in going somewhere if you’re not going to stay where all the action is. lastminute.com.au gets you the best offers on where to stay in Downtown Clayton so you don’t have to waste endless hours searching online. The trip of a lifetime is at your fingertips. Click and go!

Downtown Clayton hotels essential information

Accommodation
1,774 hotels
Lowest Price
AU$173
Highest Price
AU$291
Popular hotels
Clayton Plaza Hotel & Extended Stay, Le Méridien St. Louis Clayton, AC Hotel St. Louis Clayton, Drury Plaza Hotel St. Louis at the Arch, Hyatt Regency St. Louis at The Arch, Drury Inn & Suites St. Louis Union Station, Hollywood Casino & Hotel St. Louis, River City Casino & Hotel, Pear Tree Inn St. Louis Airport

Most recent Downtown Clayton hotel reviews

More ways to explore Downtown Clayton