21C Museum Hotel St Louis

4.5 star property

Photo gallery for 21C Museum Hotel St Louis

Exterior
Room, 1 King Bed, Corner
Bar (on property)
Indoor pool
1 bedroom, in-room safe, desk, laptop workspace

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

Map
1528 Locust street, St. Louis, MO, 63103
  • St. Louis Union Station
    ‪6 min walk‬
  • Enterprise Center
    ‪6 min walk‬
  • City Museum
    ‪6 min walk‬
  • St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Room options

Loft, 2 Queen Beds

  • Sleeps 4
  • 2 Queen Beds

Luxury Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

Room (Bunk Bed)

8.0 out of 10
Very good
(5 reviews)
  • Sleeps 2
  • 1 Twin Bunk Bed

Deluxe Room, Accessible (Accessible)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (Library)

  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed (21C)

  • Sleeps 2
  • 1 King Bed

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(56 reviews)
  • 29 sq m
  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 Double Bed, Accessible

  • Sleeps 2
  • 1 Double Bed

Deluxe Double Room, 2 Queen Beds

8.2 out of 10
Very good
(16 reviews)
  • 34 sq m
  • Sleeps 4
  • 2 Queen Beds

Deluxe Room, 1 Double Bed, Accessible

  • Sleeps 4
  • 1 Double Bed

Room, 1 King Bed, Corner

8.8 out of 10
Excellent
(19 reviews)
  • 30 sq m
  • City view
  • Sleeps 2
  • 1 King Bed

Suite, 1 King Bed

  • Sleeps 2
  • 1 King Bed

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • Sleeps 2
  • 1 King Bed

Luxury Double Room, 2 Queen Beds

8.8 out of 10
Excellent
(15 reviews)
  • 39 sq m
  • Sleeps 4
  • 2 Queen Beds

Similar properties

About the area

St. Louis

A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of Enterprise Center and City Museum. .This luxury hotel is 0.6 mi (1 km) from St. Louis Union Station and 0.7 mi (1.1 km) from America's Center Convention Complex.

What's nearby

  • St. Louis Union Station - 6 min walk - 0.6 km
  • Enterprise Center - 6 min walk - 0.6 km
  • City Museum - 6 min walk - 0.6 km
  • Busch Stadium - 14 min walk - 1.2 km
  • Gateway Arch - 2 min drive - 1.8 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪Rosalita's Cantina - ‬6 min walk
  • ‪Grand Hall Lounge Union Station - ‬11 min walk
  • ‪Hair of the Dog - ‬7 min walk
  • ‪Peabody Lounge - ‬6 min walk
  • ‪Medina Mediterranean Grill - ‬5 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
Make yourself at home in one of the 104 air-conditioned rooms featuring espresso makers and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have complimentary toiletries and hair dryers. Conveniences include phones, as well as safes and desks.
Don't miss out on the many recreational opportunities, including an indoor pool, a steam room, and a fitness center. Additional amenities at this hotel include complimentary wireless internet access, concierge services, and a banquet hall.
Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee.
Featured amenities include a business center, dry cleaning/laundry services, and a 24-hour front desk.
Cooked-to-order breakfasts are available for a surcharge and are served each morning between 6:30 AM and 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Languages

English

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoke-free property

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 861 out of 1192 reviews
Rating 8 - Good. 181 out of 1192 reviews
Rating 6 - Okay. 67 out of 1192 reviews
Rating 4 - Poor. 37 out of 1192 reviews
Rating 2 - Terrible. 46 out of 1192 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

6/10 Okay

Arron

Business traveller
Liked: Staff & service, amenities
Disliked: Cleanliness, property conditions & facilities
I’ve been visiting St. Louis for over 12 years and used to try different hotels — until I stayed at 21c. Since that first visit, I haven’t stayed anywhere else. It had a fresh energy, a unique atmosphere, and the kind of people that made it feel exciting. The real standout has always been the staff, especially the bar and restaurant team — people like Carson, Cam, and JoJo. Their effort, warmth, and attention to detail make every stay feel like more than just a hotel visit. Over time, they’ve become familiar faces and genuine friends. But on my most recent stay, I was let down — not by them, but by housekeeping and management. My room simply wasn’t clean: mould in the shower, someone else’s hair, stains left untouched, and amenities not replaced. Once you see it, you start noticing more — and unfortunately, I did. I raised it with the team (not even their job to fix) and they went out of their way to make things right — offering a credit and even leaving a bottle of their own gin in my room. Lovely gestures, truly appreciated — but the mould was still there the next day. The issue wasn’t fixed. For a short stay, I’d still recommend it. But for anything longer, if you value cleanliness and comfort, I’d think twice. The team out front are brilliant — but they’re being let down by what’s happening behind the scenes.
Stayed 9 nights in Mar 2025

10/10 Excellent

Steve

Stayed 1 night in Mar 2025

8/10 Good

JANA

Travelled with group
Liked: Staff & service, amenities, property conditions & facilities
The property is very special, with a historic and totally renovated pool and spa, and a large art exhibit. The bar and lobby are loaded with art and beautifully designed surroundings. Only one of three elevators were working this week, so a lot of waiting and frankly feeling unsafe. The breakfast restaurant is good. There is no lunch option and the front desk has zero intel regarding outside options. The dinner menu is ridiculously expensive and not very enticing. Drinks are crazy expensive ($14 for 3 oz of sav blanc) The valet is $45/night in kind of a rundown, crummy neighborhood.
Stayed 2 nights in Mar 2025

10/10 Excellent

Veronica

Liked: Cleanliness, staff & service, property conditions & facilities
Beautiful hotel. Amazing indoor pool. My kids Loved the bunk beds.
Stayed 2 nights in Mar 2025

10/10 Excellent

Rebecca

Travelled with partner
Liked: Amenities
We stayed here for a night while we were in town to watch the Blues. It's close enough to walk to the stadium or take a quick uber. It was close to union station too. Wonderful hotel! We will be back.
Stayed 1 night in Mar 2025

10/10 Excellent

Jocelynne

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in Mar 2025

10/10 Excellent

Verified traveller

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Great
Stayed 1 night in Feb 2025

10/10 Excellent

Christopher

Travelled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 4 nights in Mar 2025

10/10 Excellent

Ashley

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

10/10 Excellent

Tracey

Travelled with family, Business traveller
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We had a couple of hurdles when we arrived and the staff was so kind and went out of their way to make it right. I would recommend this place to anyone and will definitely stay here again. Kind people make everything else seem so minor. I appreciate everyone I have come in contact with during this stay!
Stayed 1 night in Mar 2025

2/10 Terrible

Deborah

Liked: Cleanliness, property conditions & facilities
Stayed 1 night in Mar 2025

10/10 Excellent

Alexus

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

8/10 Good

Ju Hui

Stayed 2 nights in Mar 2025

10/10 Excellent

Bryan

Travelled with partner
Liked: Cleanliness, staff & service, property conditions & facilities
Great boutique hotel in downtown St. Louis, the hotel was busy when we checked in and the front desk staff was a bit harried, but they gave us the essential information we needed. The art gallery on the second floor was a great addition to our stay, as was the on sight restaurant, The Idol Wolf, amazing food, and service. The hotel itself has a very cool, and eclectic vibe, but is beginning to look a little “run down”. But overall a good experience, we will definitely stay here again if we are ever in the area.
Stayed 1 night in Mar 2025

10/10 Excellent

Lisa

Travelled with group
Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 1 night in Mar 2025

10/10 Excellent

chastity

Travelled with partner
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Really clean and updated. The museum on the 2nd floor was nice to browse. Valet guys were funny and friendly. The gal at check in was not as friendly. Would stay here again for convenience to concerts, sporting events, etc.
Stayed 1 night in Mar 2025

10/10 Excellent

Joseph

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

March 21c couples stay

The hotel, bar, restaurants and art were amazing. Would definitely stay here again. Some improvements; need a hair dryer in room without asking, need hooks in bathroom and need higher quality toilet paper.
Stayed 2 nights in Mar 2025

10/10 Excellent

Brandi

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 3 nights in Mar 2025

10/10 Excellent

Latisha

Business traveller
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Very nice and comfortable hotel.
Stayed 2 nights in Jan 2025

10/10 Excellent

Amy

Stayed 4 nights in Feb 2025

10/10 Excellent

Jonathan

Stayed 5 nights in Feb 2025

6/10 Okay

Erin

Travelled with family
Disliked: Cleanliness
It was disappointing to walk into hotel and see dirty carpeted stairs, glasses from the night before left in the pool and health club areas and a bathroom barn door that didn't close all the way in our room. No towels were available for pool use, we were told by the rude attendant to use our room towels and it was quite a process to get extra clean towels to use after showers. This hotel has a lot of potential but was underwhelming. I would not stay here again.
Stayed 1 night in Mar 2025

8/10 Good

Andrew

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort

Cool, hip downtown spot!

First time staying here and aside from a few issues, it was a worthwhile stay. Hotel is an old YMCA that has been modernized and upgraded in a major way! Food options are worthy and showcased art is a nice bonus. Pool is also great! Except for a few “misses”this place would be Excellent.
Stayed 4 nights in Feb 2025

6/10 Okay

Jerry, Grimes

Stayed 1 night in Mar 2025

10/10 Excellent

Alexander

Business traveller
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
I like
Stayed 2 nights in Feb 2025