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21C Museum Hotel St Louis

4.5 star property

Photo gallery for 21C Museum Hotel St Louis

Interior
Dining
Loft, 2 Queen Beds
Exterior
Billiards

Reviews

9.0 out of 10
Wonderful

Popular amenities

  • Bar

Explore the area

View map
1528 Locust street, St. Louis, MO, 63103
  • Place, St. Louis Union Station
    ‪6 min walk‬
  • Place, Enterprise Center
    ‪6 min walk‬
  • Place, Busch Stadium
    ‪14 min walk‬
  • Airport, St. Louis, MO (STL-Lambert-St. Louis Intl.)
    ‪21 min drive‬

Room options

View all photos for Loft, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Loft, 2 Queen Beds

  • 40 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Luxury Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Luxury Suite, 1 King Bed

  • 51 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Room (Bunk Bed)

1 bedroom, in-room safe, desk, laptop workspace

Room (Bunk Bed)

8.0 out of 10
Very good
(6 reviews)
  • 22 sq m
  • 1 bedroom
  • Sleeps 2
  • 1 Twin Bunk Bed

View all photos for Deluxe Room, Accessible (Accessible)

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, Accessible (Accessible)

  • 25 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (Library)

1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed (Library)

  • 68 sq m
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

Suite, 1 King Bed (21C)

  • 104 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Room, 1 Double Bed, Accessible

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Deluxe Room, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 King Bed

9.2 out of 10
Wonderful
(74 reviews)
  • 29 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 Double Bed, Accessible

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 Double Bed, Accessible

  • 48 sq m
  • Sleeps 2
  • 1 Double Bed

View all photos for Deluxe Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Double Room, 2 Queen Beds

8.6 out of 10
Excellent
(20 reviews)
  • 34 sq m
  • Sleeps 4
  • 2 Queen Beds

View all photos for Deluxe Room, 1 Double Bed, Accessible

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Room, 1 Double Bed, Accessible

  • 36 sq m
  • Sleeps 4
  • 1 Double Bed

View all photos for Room, 1 King Bed, Corner

1 bedroom, in-room safe, desk, laptop workspace

Room, 1 King Bed, Corner

8.8 out of 10
Excellent
(25 reviews)
  • 30 sq m
  • City view
  • Sleeps 2
  • 1 King Bed

View all photos for Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Suite, 1 King Bed

  • 48 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Deluxe Suite, 1 King Bed

1 bedroom, in-room safe, desk, laptop workspace

Deluxe Suite, 1 King Bed

9.2 out of 10
Wonderful
(5 reviews)
  • 48 sq m
  • Sleeps 2
  • 1 King Bed

View all photos for Luxury Double Room, 2 Queen Beds

1 bedroom, in-room safe, desk, laptop workspace

Luxury Double Room, 2 Queen Beds

9.2 out of 10
Wonderful
(21 reviews)
  • 39 sq m
  • Sleeps 4
  • 2 Queen Beds

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4.4 out of 5, Excellent, 1,047 reviews
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includes taxes & fees
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About the area

St. Louis

A stay at 21C Museum Hotel St Louis places you in the heart of St. Louis, within a 10-minute walk of City Museum and Enterprise Center. .This luxury hotel is 0.6 mi (1 km) from St. Louis Union Station and 0.7 mi (1.1 km) from America's Center Convention Complex.

What's nearby

  • St. Louis Union Station - 6 min walk - 0.6 km
  • Enterprise Center - 6 min walk - 0.6 km
  • City Museum - 6 min walk - 0.6 km
  • Busch Stadium - 14 min walk - 1.2 km
  • Gateway Arch - 2 min drive - 1.8 km

Getting around

  • 8th and Pine Station - 13 min walk
  • St. Louis Gateway Station - 14 min walk
  • St. Louis Lambert Intl. Airport (STL) - 26 min drive

Restaurants

  • ‪City Museum Rooftop Cafe - ‬5 min walk
  • ‪Medina Grill - ‬5 min walk
  • ‪Budweiser Kiel Club - ‬6 min walk
  • ‪White Knight Diner - ‬4 min walk
  • ‪Idol Wolf - ‬1 min walk

About this property

21C Museum Hotel St Louis

Luxury hotel with a fitness center and a steam room
21C Museum Hotel St Louis offers 104 air-conditioned accommodations with espresso makers and safes. Flat-screen televisions come with premium cable channels. Bathrooms include bathrobes, complimentary toiletries, and hair dryers.

This St. Louis hotel provides complimentary wireless Internet access. Business-friendly amenities include desks, desk chairs, and phones. Additionally, rooms include complimentary bottled water and irons/ironing boards. Change of towels and change of bedsheets can be requested. Housekeeping is provided daily.

Recreational amenities at the hotel include an indoor pool, a steam room, and a fitness center.
Guests can pamper themselves by indulging in the onsite spa services. Services include massages.
Make yourself at home in one of the 104 air-conditioned rooms featuring espresso makers and flat-screen televisions. Complimentary wireless internet access keeps you connected, and cable programming is available for your entertainment. Bathrooms have complimentary toiletries and hair dryers. Conveniences include phones, as well as safes and desks.
Don't miss out on the many recreational opportunities, including an indoor pool, a steam room, and a fitness center. Additional amenities at this hotel include complimentary wireless internet access, concierge services, and a banquet hall.
Enjoy a meal at the restaurant or snacks in the coffee shop/cafe. The hotel also offers room service (during limited hours). Wrap up your day with a drink at the bar/lounge. Cooked-to-order breakfasts are available daily from 6:30 AM to 1:00 PM for a fee.
Featured amenities include a business center, dry cleaning/laundry services, and a 24-hour front desk.
Cooked-to-order breakfasts are available for a surcharge and are served each morning between 6:30 AM and 1:00 PM.
21C Museum Hotel St Louis has a restaurant on site.
Room service (during limited hours) is available.

Property amenities

Internet

  • Available in all rooms: Free WiFi
  • Available in some public areas: Free WiFi

Parking and transport

  • Valet parking on site (USD 50 per day; includes in/out privileges)

Food and drink

  • Daily cooked-to-order breakfast available 6:30 AM to 1:00 PM for a fee: USD 10 to 25 per person
  • A bar/lounge
  • A coffee shop/cafe
  • A restaurant

Things to do

  • Billiards/pool table
  • Gym
  • Indoor pool
  • Steam room

Family friendly

  • Indoor pool
  • Soundproofed rooms

Conveniences

  • 24-hour front desk
  • ATM
  • Luggage storage
  • Vending machine

Guest services

  • Change of bedsheets (on request)
  • Change of towels on request
  • Concierge services
  • Dry cleaning/laundry service
  • Housekeeping (daily)

Business services

  • Business centre
  • Meeting rooms

Spa

  • Massage
  • Spa services

Accessibility

  • If you have requests for specific accessibility needs, please contact the property using the information on the reservation confirmation received after booking.
  • Area rugs in room
  • Braille/raised signage
  • Grab bar in shower (89 centimetre high)
  • Handrails in stairways (91 centimetre high)
  • Lever door handles
  • Lift (107 centimetre wide door)
  • Magnifying mirror
  • Pool hoist on site
  • Stair-free path to entrance
  • Thin carpet in room
  • Tile flooring in room
  • Visual fire alarm
  • Well-lit path to entrance
  • Wheelchair accessible (may have limitations)
  • Wheelchair-accessible gym
  • Wheelchair-accessible lounge
  • Wheelchair-accessible path of travel
  • Wheelchair-accessible pool
  • Wheelchair-accessible public bathroom
  • Wheelchair-accessible registration desk (91 centimetre high)
  • Wheelchair-accessible restaurant
  • Wheelchair-accessible spa
  • Wheelchairs on site

More

  • Banquet hall
  • Biodegradable coffee stirrers available
  • Biodegradable drinking straws available
  • No plastic coffee stirrers
  • No plastic drinking straws
  • No plastic soft drink bottles
  • No plastic water bottles
  • Reusable cups
  • Reusable tableware
  • Smoke-free property

Room amenities

Bedroom

  • Bedsheets provided
  • Blackout drapes

Bathroom

  • Dressing gowns
  • Free toiletries
  • Hair dryer
  • Shampoo
  • Soap
  • Toilet paper
  • Toothbrush and toothpaste (on request)
  • Towels provided

Entertainment

  • Flat-screen TV with premium digital channels

Food and drink

  • Espresso maker
  • Free bottled water
  • Limited room service

More

  • Air conditioning
  • Desk
  • Desk chair
  • Heating
  • Iron/ironing board
  • Laptop workspace
  • Phone
  • Safe
  • Soundproofed rooms

Policies

Check-in

Check-in start time: 4:00 PM; Check-in end time: 11:00 AM
Late check-in subject to availability
Minimum check-in age: 21

Check-out

Check-out before 11:00 AM

Special check-in instructions

Front desk staff will greet guests on arrival at the property

Access methods

Staffed front desk

Pets

Pets allowed for an extra charge of USD 100 per accommodation, per stay
Service animals are welcome, and are exempt from fees
Welcoming dogs only

Children and extra beds

Children are welcome
Rollaway/extra beds are not available
Cribs (infant beds) are not available

Payment types

Important information

Fees

You'll be asked to pay the following charges at the property. Fees may include applicable taxes:

  • Service fee: USD 5 per accommodation, per stay

We have included all charges provided to us by the property.

Optional extras

  • Fee for cooked-to-order breakfast: approximately USD 10 to 25 per person
  • Valet parking fee: USD 50 per day (in/out privileges)
  • Pet fee: USD 100 per accommodation, per stay
  • Service animals are exempt from fees

The above list may not be comprehensive. Fees and deposits may not include tax and are subject to change.

You need to know

Extra-person charges may apply and vary depending on property policy
Government-issued photo identification and a credit card, debit card, or cash deposit may be required at check-in for incidental charges
Special requests are subject to availability upon check-in and may incur additional charges; special requests cannot be guaranteed
This property accepts credit cards; cash is not accepted
Safety features at this property include a smoke detector and outdoor lighting

We should mention

Reservations are required for massage services; reservations can be made by contacting the property prior to arrival, using the contact information on the booking confirmation
This property welcomes guests of all sexual orientations and gender identities (LGBTQ+ friendly)

Property is also known as

21C Museum Hotel St Louis
21c Museum St Louis St Louis
21C Museum Hotel St Louis Hotel
21C Museum Hotel St Louis St. Louis
21C Museum Hotel St Louis Hotel St. Louis
21C Museum Hotel St Louis (Opening Spring 2023)

21C Museum Hotel St Louis Reviews

Reviews

9.0

Wonderful

Rating 10 - Excellent. 1002 out of 1389 reviews
Rating 8 - Good. 206 out of 1389 reviews
Rating 6 - Okay. 87 out of 1389 reviews
Rating 4 - Poor. 42 out of 1389 reviews
Rating 2 - Terrible. 52 out of 1389 reviews

9.2/10

Cleanliness

9.2/10

Staff & service

9.2/10

Amenities

9.4/10

Property conditions & facilities

9.2/10

Eco-friendliness

Reviews

8/10 Good

kayla

Travelled with group
Liked: Amenities
Not a great area but a great hotel
Stayed 1 night in Jun 2025

10/10 Excellent

Emmanuel

Liked: Cleanliness, staff & service
Stayed 1 night in Jun 2025

10/10 Excellent

Teresa

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
Excellent short stay for a Cardinals game. Perfect location. We really appreciated the assistance of the evening valet, I think his name was Kevin, who suggested and arranged a golf cart shuttle to Busch Stadium. Very comfortable, fresh room. My only suggestion for all the 21c hotels is an update to the body/hand wash with its foul smelling “rum” fragrance reminiscent of a 1970s disco filled with wafting musk aftershave 😉
Stayed 1 night in Jun 2025

6/10 Okay

Holly

Business traveller
Liked: Property conditions & facilities
The art and decor were interesting. The location was not ideal to get to shops, restaurants or the convention center. It could have been cleaner. The coffee shop had limited hours and I was never able to visit. The hotel bar was too busy with an event in the private room and it took a long time to get served at times.
Stayed 3 nights in Jun 2025

10/10 Excellent

Jeffrey

Liked: Cleanliness
Great place to stay.
Stayed 1 night in Jun 2025

10/10 Excellent

Tiffany

Stayed 1 night in Jun 2025

10/10 Excellent

Mark, Kansas City

Stayed 1 night in Jun 2025

10/10 Excellent

Yitzchok

Amazing
Stayed 3 nights in Jun 2025

2/10 Terrible

Gilles, Tabuk

Travelled with family
Disliked: Cleanliness, amenities
It is a museum hotel, but the museum is currently closed. Arrived at 6:30 PM with check-in at 3, and the room took 1.5 hours to be ready. We were given the room, but it was not clean, and the bathrobes were stained. The garbage in the bathroom was not empty. Their best proposal was to try to downgrade us from the suite we booked to a king. Service hote. We spent 2 nights and there was no night service to make the bed in the morning. What a shame.
Stayed 2 nights in Jun 2025

10/10 Excellent

Jason

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 3 nights in Jun 2025

10/10 Excellent

Denise

Liked: Cleanliness, staff & service, property conditions & facilities
Stayed 2 nights in Jun 2025

10/10 Excellent

James

Stayed 1 night in Jun 2025

2/10 Terrible

Adam

Stayed 3 nights in Jun 2025

10/10 Excellent

Kyler

Liked: Cleanliness, property conditions & facilities
Stayed 2 nights in May 2025

10/10 Excellent

Caitlin

Stayed 1 night in Jun 2025

10/10 Excellent

Allen

Travelled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
We liked that the hotel had valet parking, which made it easier than trying to find a spot to park. We drove a larger van, and trying to find a spot to park would have been hard. The hotel had a great pool and hot tub. The rooms were great, clean and comfortable.
Stayed 1 night in Jun 2025

10/10 Excellent

Lima Rose

Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Great stay
Stayed 1 night in Jun 2025

10/10 Excellent

Luis, Southaven

Travelled with family
Liked: Cleanliness, staff & service, amenities, property conditions & facilities
Excellent service of everyone in the hotel. Please don’t change and continue with excellent services.
Stayed 1 night in Jun 2025

10/10 Excellent

Juanita

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Stayed 2 nights in May 2025

10/10 Excellent

Jonathan

Stayed 2 nights in Jun 2025

10/10 Excellent

Shantelle

Stayed 3 nights in May 2025

10/10 Excellent

Meagan

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
This hotel was beautiful and fun. Super easy to walk to the r Center. The room was very modern, but pretty tiny. I wouldn’t want to need to spend a lot of time there. It was perfect for an overnight stay to attend a concert. The restaurants were food. We did dinner and breakfast. Not many food options within walking distance. We really liked the water bottles and refill stations and the pool was unique and quirky.
Stayed 1 night in Mar 2025

10/10 Excellent

Kenyatta

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
This property was a wonderful place to stay. Even though the museum in side was booked two of the three days I was there. I got a chance to see it before heading home.
Stayed 2 nights in Jun 2025

10/10 Excellent

Hasani

Travelled with partner
Liked: Cleanliness, amenities, property conditions & facilities
The pool and patio area was beautiful. Everything including the staff was 10/10.
Stayed 2 nights in Jun 2025

10/10 Excellent

Hillary

Liked: Cleanliness, staff & service, property conditions & facilities, room comfort
Amazing stay! Best hotel bar ever!!!
Stayed 3 nights in Jun 2025