Book Defiance hotels

Start date: Check-in selected.
To Date
End date: Check-out

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Defiance

Cheap Defiance hotels

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham

3 out of 5
1088 South Highway Drive Fenton MO
Fully refundableReserve now, pay when you stay
The price is AU$146 per night from 12 Feb to 13 Feb
AU$146
12 Feb - 13 Feb
includes taxes & fees
A stay at Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham places you in the heart of Fenton, within a 5-minute drive of SSM Health St. Clare Hospital ...
Opens in a new windowHeritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham
Hollywood Casino & Hotel St. Louis

Hollywood Casino & Hotel St. Louis

3.5 out of 5
777 Casino Center Drive Maryland Heights MO
Fully refundableReserve now, pay when you stay
The price is AU$235 per night from 16 Feb to 17 Feb
AU$235
16 Feb - 17 Feb
includes taxes & fees
Located in Maryland Heights, Hollywood Casino & Hotel St. Louis is on a river, just a 3-minute walk from Hollywood Casino and a 4-minute drive from Hollywood ...
Opens in a new windowHollywood Casino & Hotel St. Louis
The Wildwood Hotel

The Wildwood Hotel

3.5 out of 5
2801 Fountain Pl Wildwood MO
Fully refundableReserve now, pay when you stay
Located in Wildwood, The Wildwood Hotel is in the mountains, a 3-minute drive from Wildwood Dog Park and 6 minutes from Dr. Edmund A. Babler Memorial State ...
Opens in a new windowThe Wildwood Hotel
Save an average of 15% on thousands of hotels when you're signed in
Ameristar Casino Resort and Spa

Ameristar Casino Resort and Spa

4.5 out of 5
1 Ameristar Blvd St. Charles MO
Fully refundableReserve now, pay when you stay
The price is AU$349 per night from 16 Feb to 17 Feb
AU$349
16 Feb - 17 Feb
includes taxes & fees
A stay at Ameristar Casino Resort and Spa places you in the heart of St. Charles, steps from Ameristar Casino St. Charles and a 4-minute drive from Family ...
Opens in a new windowAmeristar Casino Resort and Spa
Courtyard by Marriott St Louis Creve Coeur

Courtyard by Marriott St Louis Creve Coeur

3 out of 5
828 N New Ballas Rd St. Louis MO
Fully refundableReserve now, pay when you stay
The price is AU$187 per night from 27 Feb to 28 Feb
AU$187
27 Feb - 28 Feb
includes taxes & fees
With a stay at Courtyard by Marriott St Louis Creve Coeur in St. Louis (Creve Coeur), you'll be a 4-minute drive from Westport Plaza and 11 minutes from Hollywood ...
Opens in a new windowCourtyard by Marriott St Louis Creve Coeur
Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West

3 out of 5
13639 Riverport Dr Maryland Heights MO
Fully refundableReserve now, pay when you stay
The price is AU$117 per night from 24 Feb to 25 Feb
AU$117
24 Feb - 25 Feb
includes taxes & fees
When you stay at Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West in Maryland Heights, you'll be near the airport, a 2-minute drive from ...
Opens in a new windowLarkspur Landing Extended Stay Suites St. Louis Riverport - Airport West
Best Western Plus The Charles Hotel

Best Western Plus The Charles Hotel

3 out of 5
1425 South 5th Street St. Charles MO
Fully refundableReserve now, pay when you stay
The price is AU$123 per night from 16 Feb to 17 Feb
AU$123
16 Feb - 17 Feb
includes taxes & fees
When you stay at Best Western Plus The Charles Hotel in St. Charles, you'll be in the historical district, within a 5-minute drive of Ameristar Casino St. Charles ...
Opens in a new windowBest Western Plus The Charles Hotel
Country Inn & Suites by Radisson, St. Charles Historic District

Country Inn & Suites by Radisson, St. Charles Historic District

2.5 out of 5
1190 S Main St St. Charles MO
Fully refundable
The price is AU$185 per night from 8 Mar to 9 Mar
AU$185
8 Mar - 9 Mar
includes taxes & fees
With a stay at Country Inn & Suites by Radisson, St. Charles Historic District in St. Charles (St. Charles Historic District), you'll be a 1-minute drive from ...
Opens in a new windowCountry Inn & Suites by Radisson, St. Charles Historic District
Drury Plaza Hotel St. Louis St. Charles

Drury Plaza Hotel St. Louis St. Charles

3 out of 5
380 Mulholland Drive St. Charles MO
Fully refundableReserve now, pay when you stay
The price is AU$216 per night from 1 Mar to 2 Mar
AU$216
1 Mar - 2 Mar
includes taxes & fees
When you stay at Drury Plaza Hotel St. Louis St. Charles in St. Charles, you'll be in the business district, within a 5-minute drive of Ameristar Casino St. ...
Opens in a new windowDrury Plaza Hotel St. Louis St. Charles
Don't see what you're looking for?
See all available properties in Defiance
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Defiance, St. Louis

Forget about spiritual fulfilment or a big bank account. Real happiness is packing your bag for a getaway in St. Louis! If you’re on your way to this exciting city, consider staying in Defiance, 50 kilometres from the centre.

The best place to kick-start your grand adventure is the Gateway Arch, St. Louis' top attraction.

If you and your BFFs are looking for a decent meal but can't be bothered travelling too far away, why not try Piazza Deli & Pizzeria? It's practically next door.

Accommodation options near Defiance

You and the gang having problems finding accommodation in Defiance? If so, the Americas Best Value Inn in Lake St Louis and the Staybridge Suites O'Fallon Chesterfield in O'Fallon are nearby alternatives that are worth looking into.

So, what are you waiting for? It's time to pick out your perfect Defiance accommodations, experiences and flights. And don't forget to tag us in your breathtaking #IntrepidTraveller snaps!

Defiance hotels essential information

Accommodation
854 hotels
Lowest Price
AU$117
Highest Price
AU$349
Popular hotels
Heritage Inn & Suites St. Louis/Fenton, Trademark by Wyndham, Hollywood Casino & Hotel St. Louis, The Wildwood Hotel, Ameristar Casino Resort and Spa, Courtyard by Marriott St Louis Creve Coeur, Larkspur Landing Extended Stay Suites St. Louis Riverport - Airport West, Best Western Plus The Charles Hotel, Country Inn & Suites by Radisson, St. Charles Historic District, Drury Plaza Hotel St. Louis St. Charles

Most recent Defiance hotel reviews

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.