Book Holiday Homes in Panama City

Start date: Check-in selected.
To Date
End date: Check-out

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in Panama City

Guest favorite close to beach golf cart & Hot Tub Pet friendly!

Guest favorite close to beach golf cart & Hot Tub Pet friendly!

Panama City Beach FL
When you stay at this vacation home in Panama City Beach, you'll be by the sea, within a 5-minute drive of Pier Park and Panama City Beaches.
Opens in a new windowGuest favorite close to beach golf cart & Hot Tub Pet friendly!
GULF FRONT OASIS, PRIVATE HEATED POOL-opt, 5 BR, GORGEOUS BEACH VIEWS, Sleeps 12

GULF FRONT OASIS, PRIVATE HEATED POOL-opt, 5 BR, GORGEOUS BEACH VIEWS, Sleeps 12

Panama City Beach FL
With a stay at this vacation home in Panama City Beach (Sunnyside), you'll be a 1-minute drive from Panama City Beaches and 6 minutes from Rosemary Beach.
Opens in a new windowGULF FRONT OASIS, PRIVATE HEATED POOL-opt, 5 BR, GORGEOUS BEACH VIEWS, Sleeps 12
Seahorse Cottage Pet Friendly, walking distance to beach

Seahorse Cottage Pet Friendly, walking distance to beach

Panama City Beach FL
With a stay at this vacation home in Panama City Beach (Bahama Beach), you'll be within a 5-minute drive of Panama City Beaches and Shipwreck Island ...
Opens in a new windowSeahorse Cottage Pet Friendly, walking distance to beach
Save an average of 15% on thousands of hotels when you're signed in
Margaritaville 6BR Retreat | Partial Gulf View

Margaritaville 6BR Retreat | Partial Gulf View

Panama City Beach FL
With a stay at this vacation home in Panama City Beach, you'll be a 4-minute walk from Panama City Beaches and within a 5-minute drive of Pier Park.
Opens in a new windowMargaritaville 6BR Retreat | Partial Gulf View
#224 Townhome Gulf Highlands on water canal

#224 Townhome Gulf Highlands on water canal

Panama City Beach FL
The price is AU$369 per night from 30 Dec to 31 Dec
AU$369
30 Dec - 31 Dec
includes taxes & fees
With a stay at this vacation home in Panama City Beach, you'll be within a 5-minute drive of Panama City Beaches and Thomas Drive.
Opens in a new window#224 Townhome Gulf Highlands on water canal
Margaritaville Resort | 6BR Beach Villa | Pool

Margaritaville Resort | 6BR Beach Villa | Pool

Panama City Beach FL
With a stay at this vacation home in Panama City Beach, you'll be on the beach, a 3-minute walk from Panama City Beaches and a 4-minute drive from Pier ...
Opens in a new windowMargaritaville Resort | 6BR Beach Villa | Pool
Entire Home with GOLF CART & just 0.2 miles from the beach! Pet-Friendly!

Entire Home with GOLF CART & just 0.2 miles from the beach! Pet-Friendly!

Panama City Beach FL
With a stay at this vacation home in Panama City Beach, you'll be a 1-minute drive from Panama City Beaches and 7 minutes from Pier Park.
Opens in a new windowEntire Home with GOLF CART & just 0.2 miles from the beach! Pet-Friendly!
Beachside Bungalow 3 Blocks from Private Beach! Just 3 miles to Pier Park!

Beachside Bungalow 3 Blocks from Private Beach! Just 3 miles to Pier Park!

Panama City Beach FL
With a stay at this vacation home in Panama City Beach (Laguna Beach), you'll be a 1-minute drive from Panama City Beaches and 6 minutes from Pier Park.
Opens in a new windowBeachside Bungalow 3 Blocks from Private Beach! Just 3 miles to Pier Park!
BRAND NEW 5br House ~ 2min walk to beach~ PrivatePool~GameRoom

BRAND NEW 5br House ~ 2min walk to beach~ PrivatePool~GameRoom

Panama City FL
With a stay at this vacation home in Panama City Beach (Lower Grand Lagoon), you'll be steps from Thomas Drive and 8 minutes by foot from Panama City ...
Opens in a new windowBRAND NEW 5br House ~ 2min walk to beach~ PrivatePool~GameRoom
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Panama City Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Panama City vacation homes are the perfect way for you to wing it.

Holiday houses in Panama City let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Panama City in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Panama City adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Panama City with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Panama City vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Panama City Holiday Homes essential information

Accommodation
3303 Holiday Homes
Lowest Price
AU$73
Highest Price
AU$369
Popular accommodation
Guest favorite close to beach golf cart & Hot Tub Pet friendly!, GULF FRONT OASIS, PRIVATE HEATED POOL-opt, 5 BR, GORGEOUS BEACH VIEWS, Sleeps 12, Seahorse Cottage Pet Friendly, walking distance to beach, Margaritaville 6BR Retreat | Partial Gulf View, #224 Townhome Gulf Highlands on water canal , Margaritaville Resort | 6BR Beach Villa | Pool, Entire Home with GOLF CART & just 0.2 miles from the beach! Pet-Friendly!, Beachside Bungalow 3 Blocks from Private Beach! Just 3 miles to Pier Park!, BRAND NEW 5br House ~ 2min walk to beach~ PrivatePool~GameRoom

Top trending hotels in Panama City

La Quinta Inn & Suites by Wyndham Panama City

La Quinta Inn & Suites by Wyndham Panama City

3 out of 5
1030 E 23rd St Panama City FL
Fully refundableReserve now, pay when you stay
The price is AU$98 per night from 30 Dec to 31 Dec
AU$98
30 Dec - 31 Dec
includes taxes & fees
A stay at La Quinta Inn & Suites by Wyndham Panama City places you in the heart of Panama City, within a 15-minute walk of Panama City Mall and Linos Park.
Opens in a new windowLa Quinta Inn & Suites by Wyndham Panama City
Comfort Inn & Suites Panama City North

Comfort Inn & Suites Panama City North

2.5 out of 5
2317 Jenks Ave Panama City FL
Fully refundableReserve now, pay when you stay
The price is AU$101 per night from 4 Jan to 5 Jan
AU$101
4 Jan - 5 Jan 2026
includes taxes & fees
Located in Panama City, Comfort Inn & Suites Panama City North is a 2-minute drive from Panama City Mall and 6 minutes from Florida State University Panama ...
Opens in a new windowComfort Inn & Suites Panama City North
Hilton Garden Inn Panama City Airport

Hilton Garden Inn Panama City Airport

3 out of 5
5625 Venture Crossings Blvd Panama City FL
Fully refundableReserve now, pay when you stay
The price is AU$164 per night from 2 Jan to 3 Jan
AU$164
2 Jan - 3 Jan 2026
includes taxes & fees
Located in Panama City, Hilton Garden Inn Panama City Airport is within a 15-minute drive of St. Andrews Bay and Museum of Man in the Sea.
Opens in a new windowHilton Garden Inn Panama City Airport
Save an average of 15% on thousands of hotels when you're signed in
Quality Inn & Suites near Panama City Beach

Quality Inn & Suites near Panama City Beach

2.5 out of 5
4128 W. Highway 98 Panama City FL
Fully refundableReserve now, pay when you stay
The price is AU$73 per night from 26 Jan to 27 Jan
AU$73
26 Jan - 27 Jan 2026
includes taxes & fees
With a stay at Quality Inn & Suites near Panama City Beach in Panama City (Bay VIew Addition), you'll be within a 15-minute drive of Shipwreck Island Waterpark ...
Opens in a new windowQuality Inn & Suites near Panama City Beach
Don't see what you're looking for?
See all available properties in Panama City
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.