Book Holiday Homes in Panacea

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in Panacea

BEACHFRONT!  1 acre PRIVACY!  Million Dollar view from EVERY Room!

BEACHFRONT! 1 acre PRIVACY! Million Dollar view from EVERY Room!

Alligator Point
Located in Panacea, this vacation home is by the ocean, within a 15-minute drive of Bald Point State Park and Public Beach Access.
BEACHFRONT! 1 acre PRIVACY! Million Dollar view from EVERY Room!
Pet friendly
Kayak with the manatees

Pet friendly Kayak with the manatees

2 out of 5
Crawfordville
With a stay at this vacation home in Crawfordville, you'll be within a 10-minute drive of Wakulla Springs State Park and Wildwood Golf Club.
Pet friendly Kayak with the manatees
Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock

Panacea
With a stay at this vacation home in Panacea, you'll be on the beach, just steps from Public Beach Access and a 3-minute drive from Alligator Point Beach.
Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock
Save an average of 15% on thousands of hotels when you're signed in
Ocean View | 3 Bed, 2 Bath

Ocean View | 3 Bed, 2 Bath

Panacea
Located in Panacea, this vacation home is by the ocean, within a 15-minute drive of Bald Point State Park and Public Beach Access.
Ocean View | 3 Bed, 2 Bath
Private Beach + Dock: Waterfront Panacea Retreat!

Private Beach + Dock: Waterfront Panacea Retreat!

Panacea
Located in Panacea, this vacation home is by the ocean, a 3-minute drive from Bayside Marina and 6 minutes from Mashes Sand Beach.
Private Beach + Dock: Waterfront Panacea Retreat!
Dragonfly on the Canal

Dragonfly on the Canal

2 out of 5
Crawfordville
Located in Crawfordville, this vacation home is by the sea, within a 15-minute drive of Shell Point Beach and Wildwood Golf Club.
Dragonfly on the Canal
Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.

Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.

Alligator Point
When you stay at this vacation home in Panacea, you'll be on the beach and within a 5-minute drive of Bald Point State Park.
Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs.
Hidden Gem of St. Teresa Beach, Fl - 2/2 + bonus room

Hidden Gem of St. Teresa Beach, Fl - 2/2 + bonus room

2 out of 5
Sopchoppy
Located in Panacea, this vacation home is by the ocean, a 1-minute drive from Wilson Beach and 6 minutes from FSU Coastal & Marine Lab.
Hidden Gem of St. Teresa Beach, Fl - 2/2 + bonus room
Waterfront Escape w/ Balcony on Shell Point Beach!

Waterfront Escape w/ Balcony on Shell Point Beach!

Crawfordville
When you stay at this vacation home in Crawfordville, you'll be on the waterfront and 3 minutes by foot from Shell Point Beach.
Waterfront Escape w/ Balcony on Shell Point Beach!
Don't see what you're looking for?
See all available properties in Panacea
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Panacea Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Panacea vacation homes are the perfect way for you to wing it.

Holiday houses in Panacea let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Panacea in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Panacea adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Panacea with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Panacea vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Panacea Holiday Homes essential information

Accommodation
212 Holiday Homes
Lowest Price
Highest Price
Popular accommodation
BEACHFRONT! 1 acre PRIVACY! Million Dollar view from EVERY Room! , Pet friendly Kayak with the manatees, Skipper-extends from Beach Front to Harbor with Kayaks, Pickleball & Dock, Ocean View | 3 Bed, 2 Bath, Private Beach + Dock: Waterfront Panacea Retreat!, Dragonfly on the Canal, Tiki House is a Unique Beach Front gathering spot for family, friends and PUPs., Hidden Gem of St. Teresa Beach, Fl - 2/2 + bonus room, Waterfront Escape w/ Balcony on Shell Point Beach!

Top trending hotels in Panacea

The Panacea Motel

The Panacea Motel

2 out of 5
1545 Coastal Hwy, Panacea, FL
Located in Panacea, The Panacea Motel is in a rural location, within a 5-minute drive of Panacea Springs and Woolley Park.
The Panacea Motel
 Secluded Florida Beach Bungalow SPECIAL!!! 10% OFF ANYTIME NOW-JUNE 13TH

Secluded Florida Beach Bungalow SPECIAL!!! 10% OFF ANYTIME NOW-JUNE 13TH

Panacea
When you stay at this vacation home in Panacea, you'll be near the beach and steps from Bald Point State Park.
Secluded Florida Beach Bungalow SPECIAL!!! 10% OFF ANYTIME NOW-JUNE 13TH
Hideaway Beach Cottage on waterfront with amazing views.

Hideaway Beach Cottage on waterfront with amazing views.

Panacea
Located in Panacea, this cottage is by the ocean, a 3-minute drive from Bayside Marina and 5 minutes from Mashes Sand Beach.
Hideaway Beach Cottage on waterfront with amazing views.
Save an average of 15% on thousands of hotels when you're signed in
5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch

Panacea
Located in Panacea, this vacation home is by the ocean, within a 15-minute drive of Bald Point State Park and Public Beach Access.
5 Bedroom Beach House Slps 12 - Private Beach - Shells - Fishing -Screened porch
Don't see what you're looking for?
See all available properties in Panacea
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.