Book Holiday Homes in East St. Louis

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Featured Holiday Homes in East St. Louis

Centrally located in the Tower Grove East neighborhood!

Centrally located in the Tower Grove East neighborhood!

St. Louis MO
The price is AU$239 per night from 29 Dec to 30 Dec
AU$239
29 Dec - 30 Dec
includes taxes & fees
With a stay at this vacation home in St. Louis (Tower Grove East), you'll be within a 5-minute drive of St. Louis Union Station and St. Louis University.
Opens in a new windowCentrally located in the Tower Grove East neighborhood!
Private House - Sleeps 8 - 13 Min to Downtown STL

Private House - Sleeps 8 - 13 Min to Downtown STL

Caseyville IL
Located in Caseyville, this vacation home is within a 15-minute drive of Busch Stadium and Dome at America’s Center.
Opens in a new windowPrivate House - Sleeps 8 - 13 Min to Downtown STL
Entire 4BR Home near Lafayette Square

Entire 4BR Home near Lafayette Square

St. Louis MO
The price is AU$421 per night from 4 Jan to 5 Jan
AU$421
4 Jan - 5 Jan 2026
includes taxes & fees
With a stay at this vacation home in St. Louis (The Gate), you'll be within a 5-minute drive of St. Louis Union Station and Busch Stadium.
Opens in a new windowEntire 4BR Home near Lafayette Square
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Artsy Creative Haven Home St. Louis Art District

Artsy Creative Haven Home St. Louis Art District

St. Louis MO
Located in St. Louis (Grand Center), this vacation home is within a 15-minute walk of Fox Theater and St. Louis University.
Opens in a new windowArtsy Creative Haven Home St. Louis Art District
Historic luxury retreat

Historic luxury retreat

St Louis MO
With a stay at this vacation home in St. Louis (Lafayette Square), you'll be within a 5-minute drive of St. Louis Union Station and Busch Stadium.
Opens in a new windowHistoric luxury retreat
Modern Downtown Getaway w/ Yard & Grill

Modern Downtown Getaway w/ Yard & Grill

St. Louis MO
With a stay at this vacation home, you'll be centrally located in St. Louis, within a 5-minute drive of St. Louis Union Station and St. Louis University.
Opens in a new windowModern Downtown Getaway w/ Yard & Grill
Modern Downtown Haven: Near STL Zoo, Arch & Park

Modern Downtown Haven: Near STL Zoo, Arch & Park

St. Louis MO
With a stay at this vacation home, you'll be centrally located in St. Louis, within a 5-minute drive of St. Louis Union Station and St. Louis University.
Opens in a new windowModern Downtown Haven: Near STL Zoo, Arch & Park
Spacious City Retreat w/ 2 Car Garage by StayLage

Spacious City Retreat w/ 2 Car Garage by StayLage

2 out of 5
St Louis MO
With a stay at this vacation home, you'll be centrally located in St. Louis, within a 5-minute drive of St. Louis Union Station and Busch Stadium.
Opens in a new windowSpacious City Retreat w/ 2 Car Garage by StayLage
3BR St. Louis Home | Games + Free Parking

3BR St. Louis Home | Games + Free Parking

St. Louis MO
With a stay at this vacation home, you'll be centrally located in St. Louis, within a 5-minute drive of St. Louis Union Station and St. Louis University.
Opens in a new window3BR St. Louis Home | Games + Free Parking
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

East St. Louis Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our East St. Louis vacation homes are the perfect way for you to wing it.

Holiday houses in East St. Louis let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of East St. Louis in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local East St. Louis adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in East St. Louis with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of East St. Louis vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

East St. Louis Holiday Homes essential information

Accommodation
169 Holiday Homes
Lowest Price
AU$116
Highest Price
AU$421
Popular accommodation
Centrally located in the Tower Grove East neighborhood!, Private House - Sleeps 8 - 13 Min to Downtown STL, Entire 4BR Home near Lafayette Square, Artsy Creative Haven Home St. Louis Art District, Historic luxury retreat, Modern Downtown Getaway w/ Yard & Grill, Modern Downtown Haven: Near STL Zoo, Arch & Park, Spacious City Retreat w/ 2 Car Garage by StayLage, 3BR St. Louis Home | Games + Free Parking

Top trending hotels in East St. Louis

Casino Queen Hotel

Casino Queen Hotel

3 out of 5
200 Front Street East St. Louis IL
Fully refundableReserve now, pay when you stay
The price is AU$145 per night from 29 Dec to 30 Dec
AU$145
29 Dec - 30 Dec
includes taxes & fees
Located in East St. Louis, Casino Queen Hotel is on the waterfront, just a 3-minute walk from Malcolm W. Martin Memorial Park and a 4-minute drive from Busch ...
Opens in a new windowCasino Queen Hotel
Quality Inn & Suites near St. Louis and I-255

Quality Inn & Suites near St. Louis and I-255

2.5 out of 5
1607 Pontiac Dr East St. Louis IL
Fully refundableReserve now, pay when you stay
The price is AU$116 per night from 11 Jan to 12 Jan
AU$116
11 Jan - 12 Jan 2026
includes taxes & fees
With a stay at Quality Inn & Suites near St. Louis and I-255, you'll be centrally located in East St. Louis, within a 15-minute drive of Busch Stadium and St. ...
Opens in a new windowQuality Inn & Suites near St. Louis and I-255
The Blue House near Frank Holten State Park / Golf /Lighthouse Restaurant

The Blue House near Frank Holten State Park / Golf /Lighthouse Restaurant

East St. Louis IL
With a stay at this vacation home in East St. Louis, you'll be within a 10-minute drive of Busch Stadium and St. Louis Union Station.
Opens in a new windowThe Blue House near Frank Holten State Park / Golf /Lighthouse Restaurant
Save an average of 15% on thousands of hotels when you're signed in
Hyatt Regency St. Louis at The Arch

Hyatt Regency St. Louis at The Arch

4 out of 5
315 Chestnut St St. Louis MO
Fully refundableReserve now, pay when you stay
The price is AU$174 per night from 30 Dec to 31 Dec
AU$174
30 Dec - 31 Dec
includes taxes & fees
A stay at Hyatt Regency St. Louis at The Arch places you in the heart of St. Louis, within a 10-minute walk of Busch Stadium and Gateway Arch.
Opens in a new windowHyatt Regency St. Louis at The Arch
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.