Book Holiday Homes in St. James

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Featured Holiday Homes in St. James

The Concord: A charming 2-bed 2-bath pet friendly house in historic Saint James

The Concord: A charming 2-bed 2-bath pet friendly house in historic Saint James

Saint James MO
The price is AU$328 per night from 5 Jan to 6 Jan
AU$328
5 Jan - 6 Jan 2026
includes taxes & fees
Located in St. James, this vacation home is within a 10-minute drive of Rosati Winery Museum and Heinrichshaus Vineyard And Winery.
Opens in a new windowThe Concord: A charming 2-bed 2-bath pet friendly house in historic Saint James
The James Stay on Historic Route 66, minutes away from Wineries & Restaurants

The James Stay on Historic Route 66, minutes away from Wineries & Restaurants

Saint James MO
The price is AU$258 per night from 24 Dec to 25 Dec
AU$258
24 Dec - 25 Dec
includes taxes & fees
With a stay at this vacation home in St. James, you'll be within a 5-minute drive of Meramec Vineyards and St. James Winery.
Opens in a new windowThe James Stay on Historic Route 66, minutes away from Wineries & Restaurants
Peaceful relaxing and fun

Peaceful relaxing and fun

Salem MO
When you stay at this vacation home in Salem, you'll be on a lake and 15 minutes by car from Salem memorial hospital.
Opens in a new windowPeaceful relaxing and fun
Save an average of 15% on thousands of hotels when you're signed in
Townside Blue House

Townside Blue House

Saint James MO
The price is AU$267 per night from 24 Dec to 25 Dec
AU$267
24 Dec - 25 Dec
includes taxes & fees
Located in St. James, this vacation home is within a 5-minute drive of Meramec Vineyards and St. James Winery.
Opens in a new windowTownside Blue House
Luxury Home in Woods w/ Easy Access to Large Private Gravel Bar on Meramec River

Luxury Home in Woods w/ Easy Access to Large Private Gravel Bar on Meramec River

Steelville MO
Located in Steelville, this vacation home is on the waterfront, within a 15-minute drive of Meramec River and Mark Twain National Forest.
Opens in a new windowLuxury Home in Woods w/ Easy Access to Large Private Gravel Bar on Meramec River
Cozy Modern Farmhouse that Sleeps 8

Cozy Modern Farmhouse that Sleeps 8

Rolla MO
Located in Rolla, this vacation home is within a 5-minute drive of Ponzer Park and Cedar Street Playhouse.
Opens in a new windowCozy Modern Farmhouse that Sleeps 8
Vineyard Ridge Farmhouse

Vineyard Ridge Farmhouse

Saint James MO
The price is AU$315 per night from 29 Dec to 30 Dec
AU$315
29 Dec - 30 Dec
includes taxes & fees
When you stay at this vacation home in St. James, you'll be within a 10-minute drive of Rosati Winery Museum and Heinrichshaus Vineyard And Winery.
Opens in a new windowVineyard Ridge Farmhouse
4 bedrooms Sleeps 14

4 bedrooms Sleeps 14

Salem MO
The price is AU$409 per night from 23 Jan to 24 Jan
AU$409
23 Jan - 24 Jan 2026
includes taxes & fees
Located in Salem, this vacation home is within a 15-minute drive of Salem memorial hospital and Mark Twain National Forest.
Opens in a new window4 bedrooms Sleeps 14
 Charming house near Maramec Spring Park, Steelville/St. James

Charming house near Maramec Spring Park, Steelville/St. James

Steelville MO
Located in Steelville, this vacation home is a 1-minute drive from Woodson K. Woods Memorial Conservation Area and 6 minutes from Maramec Spring Park.
Opens in a new window Charming house near Maramec Spring Park, Steelville/St. James
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

St. James Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our St. James vacation homes are the perfect way for you to wing it.

Holiday houses in St. James let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of St. James in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local St. James adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in St. James with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of St. James vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

St. James Holiday Homes essential information

Accommodation
70 Holiday Homes
Lowest Price
AU$100
Highest Price
AU$409
Popular accommodation
The Concord: A charming 2-bed 2-bath pet friendly house in historic Saint James , The James Stay on Historic Route 66, minutes away from Wineries & Restaurants, Peaceful relaxing and fun , Townside Blue House , Luxury Home in Woods w/ Easy Access to Large Private Gravel Bar on Meramec River, Cozy Modern Farmhouse that Sleeps 8, Vineyard Ridge Farmhouse , 4 bedrooms Sleeps 14, Charming house near Maramec Spring Park, Steelville/St. James

Top trending hotels in St. James

Greenlight Inn & Suites

Greenlight Inn & Suites

2 out of 5
110 N Outer Rd St. James MO
Fully refundableReserve now, pay when you stay
The price is AU$100 per night from 1 Jan to 2 Jan
AU$100
1 Jan - 2 Jan 2026
includes taxes & fees
A stay at Greenlight Inn & Suites places you in the heart of St. James, within a 5-minute drive of St. James Winery and Meramec Vineyards.
Opens in a new windowGreenlight Inn & Suites
Finns Motel

Finns Motel

2.5 out of 5
777 Grover St St. James MO
The price is AU$100 per night from 24 Dec to 25 Dec
AU$100
24 Dec - 25 Dec
includes taxes & fees
With a stay at Finns Motel in St. James, you'll be within a 5-minute drive of St. James Winery and Meramec Vineyards.
Opens in a new windowFinns Motel
The Concord: A charming 2-bed 2-bath pet friendly house in historic Saint James

The Concord: A charming 2-bed 2-bath pet friendly house in historic Saint James

Saint James MO
The price is AU$328 per night from 5 Jan to 6 Jan
AU$328
5 Jan - 6 Jan 2026
includes taxes & fees
Located in St. James, this vacation home is within a 10-minute drive of Rosati Winery Museum and Heinrichshaus Vineyard And Winery.
Opens in a new windowThe Concord: A charming 2-bed 2-bath pet friendly house in historic Saint James
Save an average of 15% on thousands of hotels when you're signed in
Cozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.

Cozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.

Saint James MO
The price is AU$219 per night from 27 Dec to 28 Dec
AU$219
27 Dec - 28 Dec
includes taxes & fees
With a stay at this cottage in St. James, you'll be within a 5-minute drive of St. James Winery and Meramec Vineyards.
Opens in a new windowCozy Cottage on Historic Route 66, minutes away from Wineries & Restaurants.
Don't see what you're looking for?
See all available properties in St. James
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.