Southeast Missouri Holiday Deals
Top hotels for your Southeast Missouri holiday
Drury Plaza Hotel Cape Girardeau Conference Center
Always great to save money. Having a good breakfast and supper provided by the hotel was awesome.
Reviewed on 16 May 2026
Drury Inn & Suites Sikeston, MO
Breakfast was good,pool hot tub excellent
Reviewed on 17 May 2026
Baymont Inn and Suites by Wyndham Farmington, MO
Husband noted breakfast wasn’t very good. I did not have any, so I can’t really express an opinion on that. Hotel room was clean is everything I needed to get a good nights sleep
Reviewed on 16 May 2026
Popular places to visit
Southeast Missouri State University
Take a campus tour or just explore the area of Southeast Missouri State University during your trip to Cape Girardeau. While in this family-friendly area, you can savour the top-notch restaurants.
Elephant Rocks State Park
You can take time to visit Elephant Rocks State Park during your travels to Ironton. While you're in the area, wander around the parks.
Current River State Park
Commune with nature and explore the great outdoors at Current River State Park during your travels in Salem. While you're in the area, stroll along the riverfront.
Book your Southeast Missouri holiday package
Top Picks
- Annapolis Hotels
- Bernie Hotels
- Bloomsdale Hotels
- Bonne Terre Hotels
- Brazeau Township Hotels
- Bunker Hotels
- Cadet Hotels
- Lodges in Cadet
- Romantic Hotels in Cape Girardeau
- Cape Girardeau Hotels
- Central Fredericktown Hotels
- Cherryville Hotels
- Des Arc Hotels
- Iron County Hotels
- Ste. Genevieve County Hotels
- Dexter Hotels
- Cabin Rentals in Doniphan
- Ellington Hotels
- Motels in Ellington
- Eminence Hotels
- Farmington Hotels
- Fisk Hotels
- Flat River Hotels
- French Village Hotels
- Irondale Hotels
- Ironton Hotels
- Jackson Hotels
- Leadwood Hotels
- Hotels near Madison County Courthouse
- B&B in Middle Brook
- Oak Ridge Hotels
- Holiday Homes in Park Hills
- Park Hills Hotels
- Penermon Hotels
- Farmstay in Perryville
- Perryville Hotels
- Piedmont Hotels
- Hotels with Pool in Pilot Knob
- Pilot Knob Hotels
- Cabin Rentals in Poplar Bluff
- Spa Hotels in Poplar Bluff
- Farmstay in Potosi
- Potosi Hotels
- Motels in Potosi
- Qulin Hotels
- Reynolds Hotels
- Apartment Hotels in Sikeston
- Spa Hotels in Sikeston
- Sikeston Hotels
- Motels in Sikeston
- Apartment Hotels in Southeast Missouri
- Winery Hotels in Southeast Missouri
- St Mary Hotels
- Pet Friendly Hotels in Ste Genevieve
- Ste Genevieve Hotels
- Holiday Homes in Van Buren
- Van Buren Hotels
- Viburnum Hotels
- Winona Hotels
^Savings based on all package bookings made with Flight + Hotel on lastminute.com.au from January 1, 2019 to December 31, 2019, as compared to the price of the same components booked separately. Savings will vary based on origin/destination, length of trip, stay dates and selected travel supplier(s). Savings not available on all packages.