Find Santo Spirito hotels

Start date: Check-in selected.
To Date
End date: Check-out

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Check hotel availability in Santo Spirito

Top trending hotels in Santo Spirito

Hotel Horto Convento

Hotel Horto Convento

4 out of 5
Viale Ariosto, 13 Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$220 per night from 25 Jan to 26 Jan
AU$220
25 Jan - 26 Jan 2026
includes taxes & fees
With a stay at Hotel Horto Convento in Florence (Historic Centre of Florence), you'll be within a 15-minute walk of Pitti Palace and Boboli Gardens.
Opens in a new windowHotel Horto Convento
Palazzo Mannaioni Suites

Palazzo Mannaioni Suites

4 out of 5
Via Maffia 9 - 17r Florence FI
Fully refundableReserve now, pay when you stay
A stay at Palazzo Mannaioni Suites places you in the heart of Florence, within a 10-minute walk of Pitti Palace and Ponte Vecchio.
Opens in a new windowPalazzo Mannaioni Suites
La Torre Del Cestello

La Torre Del Cestello

Via Borgo San Frediano, 8 Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$189 per night from 11 Jan to 12 Jan
AU$189
11 Jan - 12 Jan 2026
includes taxes & fees
A stay at La Torre Del Cestello places you in the heart of Florence, within a 10-minute walk of Ponte Vecchio and Pitti Palace.
Opens in a new windowLa Torre Del Cestello
Save an average of 15% on thousands of hotels when you're signed in
UNA Hotels Vittoria Firenze

UNA Hotels Vittoria Firenze

4 out of 5
Via Pisana 59 Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$245 per night from 9 Jan to 10 Jan
AU$245
9 Jan - 10 Jan 2026
includes taxes & fees
With a stay at UNA Hotels Vittoria Firenze in Florence (Oltrarno), you'll be within a 5-minute drive of Piazza di Santa Maria Novella and Fortezza da Basso.
Opens in a new windowUNA Hotels Vittoria Firenze
Oltrarno Splendid

Oltrarno Splendid

Via dei Serragli 7 Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$278 per night from 19 Jan to 20 Jan
AU$278
19 Jan - 20 Jan 2026
includes taxes & fees
A stay at Oltrarno Splendid places you in the heart of Florence, within a 10-minute walk of Pitti Palace and Ponte Vecchio.
Opens in a new windowOltrarno Splendid
Casa Santo Nome di Gesù

Casa Santo Nome di Gesù

Piazza del Carmine, 21 Florence FI
A stay at Casa Santo Nome di Gesù places you in the heart of Florence, within a 15-minute walk of Piazza di Santa Maria Novella and Pitti Palace.
Opens in a new windowCasa Santo Nome di Gesù
La Fonderia Firenze

La Fonderia Firenze

Via della Fonderia 65/A Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$182 per night from 18 Jan to 19 Jan
AU$182
18 Jan - 19 Jan 2026
includes taxes & fees
With a stay at La Fonderia Firenze, you'll be centrally located in Florence, within a 5-minute drive of Piazza di Santa Maria Novella and Fortezza da Basso.
Opens in a new windowLa Fonderia Firenze
Foresteria Valdese di Firenze - Casa per Ferie

Foresteria Valdese di Firenze - Casa per Ferie

Via dei Serragli 49 Florence FI
Fully refundableReserve now, pay when you stay
A stay at Foresteria Valdese di Firenze - Casa per Ferie places you in the heart of Florence, within a 15-minute walk of Piazza di Santa Maria Novella and Pitti ...
Opens in a new windowForesteria Valdese di Firenze - Casa per Ferie
Ottantotto Firenze

Ottantotto Firenze

Via dei Serragli 88 Florence FI
Fully refundableReserve now, pay when you stay
The price is AU$361 per night from 6 Jan to 7 Jan
AU$361
6 Jan - 7 Jan 2026
includes taxes & fees
Located in Florence (Historic Centre of Florence), Ottantotto Firenze is within a 15-minute walk of Piazza di Santa Maria Novella and Pitti Palace.
Opens in a new windowOttantotto Firenze
Don't see what you're looking for?
See all available properties in Santo Spirito
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Hotels in Santo Spirito, Florence

Good days are those where the toughest decision you have to make is which hotel to stay in. And if you’re headed to Santo Spirito, 2 kilometres from central Florence, you have a pretty sweet range to select from!

If it’s your first time in Florence, make sure you check out Cathedral of Saint Mary of the Flower. Don't stop exploring there though. Ponte Vecchio is another big-name sight to strike off your never-ending bucket list.

Getting to know Santo Spirito and its surroundings usually includes visiting Piazzale Michelangelo and Basilica of Santa Croce.

Too knackered to travel miles away? Want to book accommodation near Cathedral of Saint Mary of the Flower? Easy. Suss out the Four Seasons Hotel Firenze, The St. Regis Florence, J.K. Place Firenze, The Westin Excelsior, Florence and Golden Tower Hotel & Spa.

You'll be able to stay near Piazzale Michelangelo at a number of accommodations, such as the Portrait Firenze, Villa Cora, Helvetia & Bristol Firenze – Starhotels Collezione, Rocco Forte Hotel Savoy and Hotel Regency.

If you’re feeling a little travel-worn, head to English Cemetery. This tranquil cemetery is a great spot for some time alone in quiet contemplation. You'll find a few places to crash within stumbling distance. The LHP Suite Firenze and Hotel Torre Guelfa are super spots to kick back and spend your nights. Generations of families and neighbours have congregated and bonded together at Piazza Santa Croce. Keep the time-honoured custom alive and stop over at the square. Need a place to turn in around here? The Residence La Contessina and Hotel Kraft are popular with many visitors.

Everybody has heard accommodation horror stories about the most uncomfortable mattress you can imagine and creepy-crawly infestations. But trust us, cheap doesn't have to mean nasty. There's a ton of bargain hotels here, and topping our list are the Monte Oliveto and Convitto della Calza - Holiday Home.

You really don't need soft, fluffy bathrobes, an enticing room service menu and plush cotton sheets all of the time (but, it can be nice sometimes, right?). The upmarket options here include the UNA Hotel Vittoria and Palazzo Mannaioni Suites.

Why not grab your mates and organise night one of your getaway over a coffee at Black Spring Bookshop? It's not too far away, and there's plenty of sweet treats to keep your energy levels up. When you start craving something a bit more filling later, follow your nose to Alla Vecchia Bettola. Their tasty menu is bound to satisfy your grumbly tummy. If you've been sweet-talked into making a night of it, Eagle'S Cafè Tabacchi Lotto Superenalotto is a stone's throw away as well. (A couple more beers can't hurt, can it?)

Accommodation options near Santo Spirito

Having trouble securing a decent Santo Spirito hotel? Don't tear your hair out — there are loads of options to choose from in San Frediano and Via Maggio.

So, have a look at the Santo Spirito weather forecast, pack your best outfits and get cracking! You're just a couple of clicks away from fun nights and jaw-dropping experiences!

Santo Spirito hotels essential information

Accommodation
491 hotels
Lowest Price
AU$182
Highest Price
AU$361
Popular hotels
Hotel Horto Convento, Palazzo Mannaioni Suites, La Torre Del Cestello, UNA Hotels Vittoria Firenze, Oltrarno Splendid, Casa Santo Nome di Gesù, La Fonderia Firenze, Foresteria Valdese di Firenze - Casa per Ferie, Ottantotto Firenze

Most recent Santo Spirito hotel reviews