Book Holiday Homes in O Brien

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Featured Holiday Homes in O Brien

New riverfront home across from Rock Bluff Springs on the Suwannee river

New riverfront home across from Rock Bluff Springs on the Suwannee river

Branford FL
Located in Old Town, this vacation home is on the waterfront, within a 5-minute walk of Suwannee River and Bob's River Place.
Opens in a new windowNew riverfront home across from Rock Bluff Springs on the Suwannee river
Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

Live Oak FL
The price is AU$358 per night from 17 May to 18 May
AU$358
17 May - 18 May
includes taxes & fees
Located in Live Oak, this vacation home is on the waterfront, within a 10-minute drive of Shands Live Oak Regional Medical Center and Suwannee County Historical ...
Opens in a new windowBeautiful 2 story house overlooking the water. Has arcade & Close to the springs
The Rustic River Retreat at Ginnie Springs

The Rustic River Retreat at Ginnie Springs

High Springs FL
Stay at this holiday home in High Springs. Enjoy laundry facilities, cable/satellite TV service and air conditioning. Popular attractions Ginnie Spring and Santa ...
Opens in a new windowThe Rustic River Retreat at Ginnie Springs
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Private 12 acre Ranch sleeps up to 8 on The Santa Fe River.

Private 12 acre Ranch sleeps up to 8 on The Santa Fe River.

high springs FL
When you stay at this vacation home in Branford, you'll be on a river and steps from Santa Fe River.
Opens in a new windowPrivate 12 acre Ranch sleeps up to 8 on The Santa Fe River.
High Springs Hideaway – 4BR w/ Pool & Bar • Near Springs & UF • Walk to Town

High Springs Hideaway – 4BR w/ Pool & Bar • Near Springs & UF • Walk to Town

High Springs FL
With a stay at this vacation home in High Springs, you'll be within a 10-minute walk of High Springs Civic Center Park and High Springs Community Theater.
Opens in a new windowHigh Springs Hideaway – 4BR w/ Pool & Bar • Near Springs & UF • Walk to Town
The Coppertop Inn on The Ichetucknee River Pets are Welcome 50 per pet fee

The Coppertop Inn on The Ichetucknee River Pets are Welcome 50 per pet fee

Branford FL
Located in Branford, this vacation home is on the waterfront, within a 15-minute drive of William Guy Lemmon Memorial Park and Santa Fe River.
Opens in a new windowThe Coppertop Inn on The Ichetucknee River Pets are Welcome 50 per pet fee
Cozy 1-bedroom house in delightful High Springs

Cozy 1-bedroom house in delightful High Springs

High Springs FL
The price is AU$218 per night from 17 May to 18 May
AU$218
17 May - 18 May
includes taxes & fees
With a stay at this vacation home in High Springs, you'll be within a 10-minute walk of High Springs City Hall and High Springs Library Branch.
Opens in a new windowCozy 1-bedroom house in delightful High Springs
Suwannee River Retreat with Private Dock, Free Kayaks, and Fire pit

Suwannee River Retreat with Private Dock, Free Kayaks, and Fire pit

Mayo FL
Located in Mayo, this vacation home is on the waterfront, within a 15-minute drive of Suwannee River and Lafayette County Library.
Opens in a new windowSuwannee River Retreat with Private Dock, Free Kayaks, and Fire pit
Cozy, Peaceful and Quiet Deerwood Cottage

Cozy, Peaceful and Quiet Deerwood Cottage

Lake City FL
When you stay at this vacation home in Lake City, you'll be within a 10-minute drive of North Florida Speedway and Lake City Veterans Affairs Medical ...
Opens in a new windowCozy, Peaceful and Quiet Deerwood Cottage
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

O Brien Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our O Brien vacation homes are the perfect way for you to wing it.

Holiday houses in O Brien let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of O Brien in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local O Brien adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in O Brien with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of O Brien vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

O Brien Holiday Homes essential information

Accommodation
143 Holiday Homes
Lowest Price
AU$136
Highest Price
AU$358
Popular accommodation
New riverfront home across from Rock Bluff Springs on the Suwannee river, Beautiful 2 story house overlooking the water. Has arcade & Close to the springs, The Rustic River Retreat at Ginnie Springs, Private 12 acre Ranch sleeps up to 8 on The Santa Fe River., High Springs Hideaway – 4BR w/ Pool & Bar • Near Springs & UF • Walk to Town, The Coppertop Inn on The Ichetucknee River Pets are Welcome 50 per pet fee, Cozy 1-bedroom house in delightful High Springs, Suwannee River Retreat with Private Dock, Free Kayaks, and Fire pit, Cozy, Peaceful and Quiet Deerwood Cottage

Top trending hotels in O Brien

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien FL
When you stay at this vacation home in O Brien, you'll be on the beach and steps from Suwannee River.
Opens in a new windowRoyal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
Little River Spring Cave divers poolside Hideaway

Little River Spring Cave divers poolside Hideaway

O'Brien FL
Located in O Brien, this apartment is a 4-minute drive from Branford Public Library and 5 minutes from Ivey Memorial Park.
Opens in a new windowLittle River Spring Cave divers poolside Hideaway
La Quinta Inn & Suite by Wyndham Lake City

La Quinta Inn & Suite by Wyndham Lake City

2.5 out of 5
165NW CALI DRIVE Lake City FL
Fully refundableReserve now, pay when you stay
The price is AU$156 per night from 17 May to 18 May
AU$156
17 May - 18 May
includes taxes & fees
With a stay at La Quinta Inn & Suite by Wyndham Lake City in Lake City, you'll be within a 5-minute walk of Fresenius Medical Care at Lake City Medical Center ...
Opens in a new windowLa Quinta Inn & Suite by Wyndham Lake City
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Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

Holiday Inn Express & Suites Alachua - Gainesville Area by IHG

3.5 out of 5
16367 NW 167TH BLVD Alachua FL
Fully refundable
The price is AU$136 per night from 14 June to 15 June
AU$136
14 June - 15 June
includes taxes & fees
With a stay at Holiday Inn Express & Suites Alachua - Gainesville Area by IHG in Alachua, you'll be 10.4 mi (16.7 km) from Ruth B. Kirby Gilchrist Blue Springs ...
Opens in a new windowHoliday Inn Express & Suites Alachua - Gainesville Area by IHG
Don't see what you're looking for?
See all available properties in O Brien
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Top Picks

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^Subject to availability and chosen travel dates.