Book Holiday Homes in Muscatine

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Featured Holiday Homes in Muscatine

Lucy’s House Single Family Bungalow

Lucy’s House Single Family Bungalow

Moline IL
The price is AU$193 per night from 1 Jan to 2 Jan
AU$193
1 Jan - 2 Jan 2026
includes taxes & fees
With a stay at this vacation home in Moline, you'll be on a river, within a 5-minute drive of Mississippi River and Bend XPO.
Opens in a new windowLucy’s House Single Family Bungalow
Safe & Spacious 3BR/3BA family and pet friendly home near TBK sports complex

Safe & Spacious 3BR/3BA family and pet friendly home near TBK sports complex

Davenport IA
The price is AU$466 per night from 16 Dec to 17 Dec
AU$466
16 Dec - 17 Dec
includes taxes & fees
With a stay at this vacation home in Davenport, you'll be within a 10-minute drive of Mississippi River and NorthPark Mall.
Opens in a new windowSafe & Spacious 3BR/3BA family and pet friendly home near TBK sports complex
Spacious family home with luxe beds, fenced in back yard, heart of town!

Spacious family home with luxe beds, fenced in back yard, heart of town!

Davenport IA
With a stay at this vacation home, you'll be centrally located in Davenport, within a 10-minute drive of Mississippi River and NorthPark Mall.
Opens in a new windowSpacious family home with luxe beds, fenced in back yard, heart of town!
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Cozy Cottage Home in Rock Island

Cozy Cottage Home in Rock Island

2 out of 5
Rock Island IL
With a stay at this vacation home in Rock Island, you'll be within a 5-minute drive of Mississippi River and Augustana College.
Opens in a new windowCozy Cottage Home in Rock Island
Eldridge 4BD Family Retreat Near Top Sports Complexes

Eldridge 4BD Family Retreat Near Top Sports Complexes

Eldridge IA
The price is AU$599 per night from 5 Jan to 6 Jan
AU$599
5 Jan - 6 Jan 2026
includes taxes & fees
With a stay at this vacation home in Eldridge, you'll be within a 15-minute drive of Walnut Grove Pioneer Village and St. Ambrose University.
Opens in a new windowEldridge 4BD Family Retreat Near Top Sports Complexes
Staying at this Country Retreat Supports a Nonprofit Animal Rescue

Staying at this Country Retreat Supports a Nonprofit Animal Rescue

2 out of 5
Dixon IA
With a stay at this vacation home in Dixon, you'll be 23.6 mi (38 km) from Mississippi River and 16.8 mi (27 km) from Walnut Grove Pioneer Village.
Opens in a new windowStaying at this Country Retreat Supports a Nonprofit Animal Rescue
The Historic Castle Cicali

The Historic Castle Cicali

Davenport IA
With a stay at this vacation home in Davenport, you'll be within a 10-minute drive of Mississippi River and St. Ambrose University.
Opens in a new windowThe Historic Castle Cicali
3BR/2BA Beauty near TBK sports complex. Right off I74, close to everything!

3BR/2BA Beauty near TBK sports complex. Right off I74, close to everything!

Bettendorf IA
The price is AU$466 per night from 16 Dec to 17 Dec
AU$466
16 Dec - 17 Dec
includes taxes & fees
With a stay at this vacation home in Bettendorf, you'll be within a 5-minute drive of Mississippi River and Family Museum.
Opens in a new window3BR/2BA Beauty near TBK sports complex. Right off I74, close to everything!
Riverfront Cabin:Wrap Around Deck & 3 Season Room

Riverfront Cabin:Wrap Around Deck & 3 Season Room

Moline IL
The price is AU$352 per night from 8 Jan to 9 Jan
AU$352
8 Jan - 9 Jan 2026
includes taxes & fees
With a stay at this vacation home in Moline, you'll be on the waterfront, within a 10-minute drive of Mississippi River and SouthPark Mall.
Opens in a new windowRiverfront Cabin:Wrap Around Deck & 3 Season Room
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Muscatine Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Muscatine vacation homes are the perfect way for you to wing it.

Holiday houses in Muscatine let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Muscatine in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Muscatine adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Muscatine with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Muscatine vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Muscatine Holiday Homes essential information

Accommodation
67 Holiday Homes
Lowest Price
AU$136
Highest Price
AU$599
Popular accommodation
Lucy’s House Single Family Bungalow, Safe & Spacious 3BR/3BA family and pet friendly home near TBK sports complex, Spacious family home with luxe beds, fenced in back yard, heart of town!, Cozy Cottage Home in Rock Island, Eldridge 4BD Family Retreat Near Top Sports Complexes, Staying at this Country Retreat Supports a Nonprofit Animal Rescue, The Historic Castle Cicali, 3BR/2BA Beauty near TBK sports complex. Right off I74, close to everything! , Riverfront Cabin:Wrap Around Deck & 3 Season Room

Top trending hotels in Muscatine

Best Western Muscatine / Pearl City Hotel

Best Western Muscatine / Pearl City Hotel

2.5 out of 5
305 Cleveland St Muscatine IA
Fully refundableReserve now, pay when you stay
The price is AU$144 per night from 18 Dec to 19 Dec
AU$144
18 Dec - 19 Dec
includes taxes & fees
With a stay at Best Western Muscatine / Pearl City Hotel in Muscatine, you'll be 25.6 mi (41.1 km) from Jumer's Casino & Hotel and 26.6 mi (42.8 km) from Rhythm ...
Opens in a new windowBest Western Muscatine / Pearl City Hotel
AmericInn by Wyndham Muscatine

AmericInn by Wyndham Muscatine

2.5 out of 5
3115 Hwy 61 North Muscatine IA
Fully refundableReserve now, pay when you stay
The price is AU$136 per night from 22 Dec to 23 Dec
AU$136
22 Dec - 23 Dec
includes taxes & fees
With a stay at AmericInn by Wyndham Muscatine in Muscatine, you'll be in a shopping district, within a 10-minute drive of Mississippi River and Muscatine Aquatic ...
Opens in a new windowAmericInn by Wyndham Muscatine
Hampton Inn Muscatine

Hampton Inn Muscatine

2.5 out of 5
3303 N Port Drive Muscatine IA
Fully refundableReserve now, pay when you stay
The price is AU$154 per night from 15 Jan to 16 Jan
AU$154
15 Jan - 16 Jan 2026
includes taxes & fees
With a stay at Hampton Inn Muscatine in Muscatine, you'll be within a 10-minute drive of Mississippi River and Muscatine Aquatic Center.
Opens in a new windowHampton Inn Muscatine
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Strawberry Farm Bed & Breakfast

Strawberry Farm Bed & Breakfast

3 out of 5
3402 Tipton Rd Muscatine IA
With a stay at Strawberry Farm Bed & Breakfast in Muscatine, you'll be near the airport, within a 10-minute drive of Mississippi River and Geneva Golf and Country ...
Opens in a new windowStrawberry Farm Bed & Breakfast
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Subject to availability and chosen travel dates.