Book Holiday Homes in Mayo

Start date: Check-in selected.
To Date
End date: Check-out

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in Mayo

Escape to Serenity at Suwannee River Rest – Pet-Friendly Lodge in North Florida

Escape to Serenity at Suwannee River Rest – Pet-Friendly Lodge in North Florida

Branford FL
When you stay at this vacation home in Branford, you'll be on the waterfront, just steps from Suwannee River and Stuarts Landing Conservation Area.
Opens in a new windowEscape to Serenity at Suwannee River Rest – Pet-Friendly Lodge in North Florida
Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!

obrien FL
When you stay at this vacation home in O Brien, you'll be on the beach and steps from Suwannee River.
Opens in a new windowRoyal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!
Cabin can sleep 7:  5 Adults and 2 Kids

Cabin can sleep 7: 5 Adults and 2 Kids

Steinhatchee FL
When you stay at this vacation home in Steinhatchee, you'll be on the waterfront, within a 5-minute drive of Fort Steinhatchee Pier and Sea Hag Marina.
Opens in a new windowCabin can sleep 7: 5 Adults and 2 Kids
Save an average of 15% on thousands of hotels when you're signed in
Hatch Life in Steinhatchee Landing

Hatch Life in Steinhatchee Landing

Steinhatchee FL
When you stay at this vacation home in Steinhatchee, you'll be on a river, within a 5-minute drive of Fort Steinhatchee Pier and Sea Hag Marina.
Opens in a new windowHatch Life in Steinhatchee Landing
Beautiful Home

Beautiful Home

Perry FL
With a stay at this vacation home in Perry, you'll be on the waterfront, just a 1-minute walk from One More Cast and 7 minutes by foot from Hodges Park.
Opens in a new windowBeautiful Home
Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

Beautiful 2 story house overlooking the water. Has arcade & Close to the springs

Live Oak FL
The price is AU$343 per night from 8 Feb to 9 Feb
AU$343
8 Feb - 9 Feb
includes taxes & fees
Located in Live Oak, this vacation home is on the waterfront, within a 10-minute drive of Shands Live Oak Regional Medical Center and Suwannee County Historical ...
Opens in a new windowBeautiful 2 story house overlooking the water. Has arcade & Close to the springs
Bowman's Landing Spring House on the Santa Fe River

Bowman's Landing Spring House on the Santa Fe River

Fort White FL
With a stay at this vacation home in Fort White, you'll be on the waterfront, just steps from Fort White Wildlife and Environmental Area and a 4-minute drive ...
Opens in a new windowBowman's Landing Spring House on the Santa Fe River
Riverfront home getaway 🌴 Completely new & remodeled.

Riverfront home getaway 🌴 Completely new & remodeled.

Steinhatchee FL
With a stay at this vacation home in Steinhatchee, you'll be on the waterfront, just a 1-minute walk from Sea Hag Marina and 6 minutes by foot from Steinhatchee ...
Opens in a new windowRiverfront home getaway 🌴 Completely new & remodeled.
Dekle Beach Darling - Beautiful Sunsets and Great Fishing

Dekle Beach Darling - Beautiful Sunsets and Great Fishing

Perry FL
The price is AU$545 per night from 8 Feb to 9 Feb
AU$545
8 Feb - 9 Feb
includes taxes & fees
Located in Perry, this vacation home is by the sea, a 5-minute drive from Spring Warrior Creek Conservation Area and 8 minutes from Keaton Beach Coastal ...
Opens in a new windowDekle Beach Darling - Beautiful Sunsets and Great Fishing
Don't see what you're looking for?
See all available properties in Mayo
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Mayo Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Mayo vacation homes are the perfect way for you to wing it.

Holiday houses in Mayo let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Mayo in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Mayo adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Mayo with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Mayo vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Mayo Holiday Homes essential information

Accommodation
159 Holiday Homes
Lowest Price
AU$62
Highest Price
AU$545
Popular accommodation
Escape to Serenity at Suwannee River Rest – Pet-Friendly Lodge in North Florida, Royal Springs Riverfront Retreat on 3 acres, kayak/canoe, boat ramp, huge decks!, Cabin can sleep 7: 5 Adults and 2 Kids, Hatch Life in Steinhatchee Landing, Beautiful Home, Beautiful 2 story house overlooking the water. Has arcade & Close to the springs, Bowman's Landing Spring House on the Santa Fe River, Riverfront home getaway 🌴 Completely new & remodeled., Dekle Beach Darling - Beautiful Sunsets and Great Fishing

Top trending hotels in Mayo

Suwannee River Rendezvous

Suwannee River Rendezvous

2.5 out of 5
828 NE Primrose Rd Mayo FL
The price is AU$62 per night from 7 Feb to 8 Feb
AU$62
7 Feb - 8 Feb
includes taxes & fees
Located in Mayo, Suwannee River Rendezvous is within a 15-minute drive of Suwannee River and Lafayette County Library.
Opens in a new windowSuwannee River Rendezvous
Friendlys River Retreat private 
Rustic Camping Cabin sleeps 4+with tent camping

Friendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping

Mayo FL
The price is AU$135 per night from 18 Feb to 19 Feb
AU$135
18 Feb - 19 Feb
includes taxes & fees
Located in Mayo, this cabin is in a rural location, within a 15-minute drive of Suwannee River and Lafayette Blue Springs State Park.
Opens in a new windowFriendlys River Retreat private Rustic Camping Cabin sleeps 4+with tent camping
Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Friendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,

Mayo FL
The price is AU$116 per night from 27 Feb to 28 Feb
AU$116
27 Feb - 28 Feb
includes taxes & fees
Located in Mayo, this cabin is on a river, within a 15-minute drive of Suwannee River and Lafayette Blue Springs State Park.
Opens in a new windowFriendly's river retreat #1 cozy couples cabin in awesome Mayo with WiFi,
Save an average of 15% on thousands of hotels when you're signed in
Cindys Motel

Cindys Motel

2.5 out of 5
487 W Main St Mayo FL
Fully refundableReserve now, pay when you stay
With a stay at Cindys Motel in Mayo, you'll be a 3-minute walk from Veteran's Memorial Park of Mayo and 8 minutes by foot from Lafayette County Library.
Opens in a new windowCindys Motel
Don't see what you're looking for?
See all available properties in Mayo
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.