Book Holiday Homes in Los Santos

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Featured Holiday Homes in Los Santos

Pedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm

Pedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm

2 out of 5
Los Santos Province
Located in Pedasí, this vacation home is within a 15-minute drive of Playa El Arenal and Playa El Toro.
Opens in a new windowPedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm
Tropical Beachfront Home in Cambutal

Tropical Beachfront Home in Cambutal

Ave María Provincia de Los Santos
When you stay at this vacation home in Cambutal, you'll be on the beach and 5 minutes by foot from Los Buzos Beach.
Opens in a new windowTropical Beachfront Home in Cambutal
Chic 1-bedroom with WiFi and AC in enchanting Río Hato

Chic 1-bedroom with WiFi and AC in enchanting Río Hato

Río Hato Provincia de Coclé
Located in Rio Hato, this vacation home is a 2-minute drive from Santa Clara Beach and 9 minutes from Parroquia Santiago Apóstol de Río Hato.
Opens in a new windowChic 1-bedroom with WiFi and AC in enchanting Río Hato
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Santa Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama.

Santa Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama.

El Chirú Provincia de Coclé
When you stay at this vacation home in El Chiru, you'll be close to Parroquia Santiago Apóstol de Río Hato.
Opens in a new windowSanta Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama.
Panama Santa Clara Beach Residence

Panama Santa Clara Beach Residence

Cocle Cocle
With a stay at this vacation home in Rio Hato, you'll be on the beach, within a 15-minute drive of Playa Blanca and Santa Clara Beach.
Opens in a new windowPanama Santa Clara Beach Residence
GoldSky Hacienda with pool

GoldSky Hacienda with pool

Rio Hato Coclé Province
With a stay at this vacation home in Rio Hato, you'll be next to a golf course, within a 15-minute drive of Playa Blanca and La Casa de Lourdes Outdoor Spa.
Opens in a new windowGoldSky Hacienda with pool
Beach House / 6 People / Pool / Pet Friendly / Tourist Area

Beach House / 6 People / Pool / Pet Friendly / Tourist Area

Río Hato Provincia de Coclé
With a stay at this vacation home, you'll be centrally located in Rio Hato, a 3-minute drive from Playa Blanca and 7 minutes from Parroquia Santiago Apóstol ...
Opens in a new windowBeach House / 6 People / Pool / Pet Friendly / Tourist Area
Beachfront home + private pool, Playa Venao, Sleeps 10+

Beachfront home + private pool, Playa Venao, Sleeps 10+

Playa Venao Provincia de Los Santos
With a stay at this vacation home in Las Escobas del Venado, you'll be on the beach and 10 minutes by foot from Venao Beach.
Opens in a new windowBeachfront home + private pool, Playa Venao, Sleeps 10+
Ocean View 3 bed, 3 bath. Private pool. Steps to the beach in gated community

Ocean View 3 bed, 3 bath. Private pool. Steps to the beach in gated community

Peadsi Los Sanos
Located in Pedasí, this vacation home is by the ocean, within a 15-minute drive of Playa El Toro and Playa El Arenal.
Opens in a new windowOcean View 3 bed, 3 bath. Private pool. Steps to the beach in gated community
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Los Santos Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Los Santos vacation homes are the perfect way for you to wing it.

Holiday houses in Los Santos let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Los Santos in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Los Santos adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Los Santos with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Los Santos vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Los Santos Holiday Homes essential information

Accommodation
73 Holiday Homes
Lowest Price
AU$82
Highest Price
AU$344
Popular accommodation
Pedasi Retreat/2BD/2BA with Large Screened Deck, AC & Local Charm, Tropical Beachfront Home in Cambutal, Chic 1-bedroom with WiFi and AC in enchanting Río Hato, Santa Monica Beach House. 10 minutes from the beach! Pacific Riviera of Panama., Panama Santa Clara Beach Residence, GoldSky Hacienda with pool, Beach House / 6 People / Pool / Pet Friendly / Tourist Area, Beachfront home + private pool, Playa Venao, Sleeps 10+, Ocean View 3 bed, 3 bath. Private pool. Steps to the beach in gated community

Top trending hotels in Los Santos

Villa Marina Lodge & Condos

Villa Marina Lodge & Condos

3.5 out of 5
Playa Venao Las Escobas del Venado Los Santos
Fully refundableReserve now, pay when you stay
The price is AU$344 per night from 5 Jan to 6 Jan
AU$344
5 Jan - 6 Jan 2026
includes taxes & fees
When you stay at Villa Marina Lodge & Condos in Las Escobas del Venado, you'll be on the beach and 7 minutes by car from Venao Beach.
Opens in a new windowVilla Marina Lodge & Condos
Selina Playa Venao - Hostel

Selina Playa Venao - Hostel

3 out of 5
Playa Venao 1 Las Escobas del Venado Los Santos
Fully refundableReserve now, pay when you stay
The price is AU$82 per night from 28 Dec to 29 Dec
AU$82
28 Dec - 29 Dec
includes taxes & fees
With a stay at Selina Playa Venao - Hostel in Las Escobas del Venado, you'll be on the beach and 9 minutes by foot from Venao Beach.
Opens in a new windowSelina Playa Venao - Hostel
Selina River Venao

Selina River Venao

3 out of 5
Belisario Porras Avenue Las Escobas del Venado Provincia de Herrera
Fully refundableReserve now, pay when you stay
The price is AU$143 per night from 29 Dec to 30 Dec
AU$143
29 Dec - 30 Dec
includes taxes & fees
When you stay at Selina River Venao in Las Escobas del Venado, you'll be 5 minutes by foot from Venao Beach.
Opens in a new windowSelina River Venao
Save an average of 15% on thousands of hotels when you're signed in
Casa Lajagua

Casa Lajagua

3 out of 5
Calle principal de Pedasi Pedasí Panama
The price is AU$139 per night from 25 Jan to 26 Jan
AU$139
25 Jan - 26 Jan 2026
includes taxes & fees
Located in Pedasí, Casa Lajagua is within a 15-minute drive of Playa El Arenal and Playa El Toro.
Opens in a new windowCasa Lajagua
Don't see what you're looking for?
See all available properties in Los Santos
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

More ways to explore Los Santos

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^Subject to availability and chosen travel dates.