Book Holiday Homes in De Soto

More Flash, Less Cash - Take advantage of our Price Pledge** (even on luxey stays)

We keep it easy with the option to pay now or later on select accommodation

Book up 'til the last second - millions of rooms to crash tonight^

Featured Holiday Homes in De Soto

Pool, Lake & Patio: Sweeping De Soto Estate

Pool, Lake & Patio: Sweeping De Soto Estate

De Soto
With a stay at this property in De Soto, you'll be within a 15-minute drive of Valle Lake Beach and Eastside Community Park.
Pool, Lake & Patio: Sweeping De Soto Estate
Charming 1-bedroom house in nice Imperial with AC.  Attn! Traveling Contractors

Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors

Imperial
With a stay at this vacation home in Imperial, you'll be within a 15-minute drive of Mississippi River and Kimmswick Historical Society Museum.
Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors
Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis

Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis

Pacific
With a stay at this vacation home in Pacific, you'll be on the waterfront, within a 15-minute drive of Six Flags St. Louis and Young Conservation Area.
Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis
Save an average of 15% on thousands of hotels when you're signed in
Charming 3-bedroom house with WiFi, and fenced-in backyard in serene Byrnes Mill

Charming 3-bedroom house with WiFi, and fenced-in backyard in serene Byrnes Mill

2 out of 5
Byrnes Mill
The price is AU$487 per night from 8 Sept to 9 Sept
AU$487
8 Sept - 9 Sept
includes taxes & fees
Located in House Springs, this vacation home is within a 15-minute walk of Brynes Mill Park and Big River.
Charming 3-bedroom house with WiFi, and fenced-in backyard in serene Byrnes Mill
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations

Farmington
With a stay at this vacation home in Farmington, you'll be just steps from Farmington Skate Park and Long Memorial Park.
Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE

Park Hills
Located in Park Hills, this vacation home is in a rural location, within a 15-minute drive of St. Joe State Park and Hager Lake.
Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE
Fragrance free - spacious Ranch -safe &quiet- 4 br 2 bath

Fragrance free - spacious Ranch -safe &quiet- 4 br 2 bath

High Ridge
The price is AU$525 per night from 17 Aug to 18 Aug
AU$525
17 Aug - 18 Aug
includes taxes & fees
Located in High Ridge, this vacation home is within a 5-minute drive of Jefferson County Library Northwest Branch and High Ridge Civic Center & Park.
Fragrance free - spacious Ranch -safe &quiet- 4 br 2 bath
Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.

Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.

New Offenburg
The price is AU$485 per night from 17 Aug to 18 Aug
AU$485
17 Aug - 18 Aug
includes taxes & fees
When you stay at this vacation home in Ste Genevieve, you'll be 12 minutes by car from Weingarten Vineyard.
Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten.
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

2 out of 5
Farmington
The price is AU$361 per night from 15 Aug to 16 Aug
AU$361
15 Aug - 16 Aug
includes taxes & fees
With a stay at this vacation home in Farmington, you'll be within a 5-minute walk of Bicentennial Park and Farmington City Hall.
"The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC
Don't see what you're looking for?
See all available properties in De Soto
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

De Soto Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our De Soto vacation homes are the perfect way for you to wing it.

Holiday houses in De Soto let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of De Soto in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local De Soto adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in De Soto with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of De Soto vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

De Soto Holiday Homes essential information

Accommodation
65 Holiday Homes
Lowest Price
AU$249
Highest Price
AU$525
Popular accommodation
Pool, Lake & Patio: Sweeping De Soto Estate, Charming 1-bedroom house in nice Imperial with AC. Attn! Traveling Contractors, Lake Haven - Updated Mid Century Cabin Only 35 Mins from St. Louis, Charming 3-bedroom house with WiFi, and fenced-in backyard in serene Byrnes Mill, Charming 1-bd house in Downtown Farmington, 1block from Police & Fire stations, Bluebird Meadows with In-ground Pool and Hot Tub! 125 ACRES TO EXPLORE, Fragrance free - spacious Ranch -safe &quiet- 4 br 2 bath, Sunset Ridge - Peaceful 3-bedroom house with WiFi and AC in lovely Weingarten., "The Hideaway 2" Charming 2-bedroom house in delightful Farmington with WiFi, AC

Top trending hotels in De Soto

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG

3.5 out of 5
4800 U.S. Highway 67, De Soto, MO
Fully refundable
The price is AU$249 per night from 7 Sept to 8 Sept
AU$249
7 Sept - 8 Sept
includes taxes & fees
Located in De Soto, Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG is on a lake, within a 15-minute drive of Valle Lake Beach and Eastside ...
Holiday Inn Club Vacations Timber Creek Resort at De Soto by IHG
Pool, Lake & Patio: Sweeping De Soto Estate

Pool, Lake & Patio: Sweeping De Soto Estate

De Soto
With a stay at this property in De Soto, you'll be within a 15-minute drive of Valle Lake Beach and Eastside Community Park.
Pool, Lake & Patio: Sweeping De Soto Estate
82 Acre Hobby Farm with Lincoln Log Cabin

82 Acre Hobby Farm with Lincoln Log Cabin

De Soto
The price is AU$411 per night from 17 Aug to 18 Aug
AU$411
17 Aug - 18 Aug
includes taxes & fees
Located in De Soto, this cabin is in a rural location, within a 10-minute drive of Eastside Community Park and Joachim Park.
82 Acre Hobby Farm with Lincoln Log Cabin
Save an average of 15% on thousands of hotels when you're signed in
Lakeside Private Villa | 5-Hole Golf On-Site

Lakeside Private Villa | 5-Hole Golf On-Site

Desoto
Fully refundable
The price is AU$269 per night from 7 Sept to 8 Sept
AU$269
7 Sept - 8 Sept
includes taxes & fees
With a stay at this villa in De Soto, you'll be within a 15-minute drive of Valle Lake Beach and Eastside Community Park.
Lakeside Private Villa | 5-Hole Golf On-Site
Don't see what you're looking for?
See all available properties in De Soto
View all properties
Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.