Book Holiday Homes in Cape Girardeau

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Featured Holiday Homes in Cape Girardeau

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Anna
With a stay at this vacation home, you'll be centrally located in Anna, within a 15-minute drive of Shawnee National Forest and Shawnee Community College.
Opens in a new windowSpacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
* On the Wine Trail * Hot Tub * Wi-Fi *

* On the Wine Trail * Hot Tub * Wi-Fi *

Alto Pass
With a stay at this vacation home, you'll be centrally located in Alto Pass, steps from Shawnee National Forest and 15 minutes by foot from Peachbarn ...
Opens in a new window* On the Wine Trail * Hot Tub * Wi-Fi *
Beautiful location in the secluded woods

Beautiful location in the secluded woods

Pomona
The price is AU$277 per night from 30 Sept to 1 Oct
AU$277
30 Sept - 1 Oct
includes taxes & fees
When you stay at this vacation home in Pomona, you'll be 1 minutes by foot from Shawnee National Forest.
Opens in a new windowBeautiful location in the secluded woods
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* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *

Alto Pass
With a stay at this vacation home, you'll be centrally located in Alto Pass, steps from Shawnee National Forest and 15 minutes by foot from Peachbarn ...
Opens in a new window* Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Cape Girardeau
The price is AU$157 per night from 30 Sept to 1 Oct
AU$157
30 Sept - 1 Oct
includes taxes & fees
With a stay at this vacation home in Cape Girardeau, you'll be within a 5-minute walk of Mississippi River and Shawnee National Forest.
Opens in a new windowLittle Blue Cottage on Spanish
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau
The price is AU$379 per night from 30 Sept to 1 Oct
AU$379
30 Sept - 1 Oct
includes taxes & fees
When you stay at this vacation home in Cape Girardeau, you'll be on a river, just steps from Shawnee National Forest and Mississippi River.
Opens in a new windowSerenity South -- Gardens, River-Views, and Refreshing Space
Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

Anna
With a stay at this vacation home in Anna, you'll be within a 15-minute drive of Shawnee National Forest and Shawnee Community College.
Opens in a new windowSpacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck
Sunset Ridge - Cabin 4

Sunset Ridge - Cabin 4

Cobden
With a stay at this vacation home in Cobden, you'll be steps from Shawnee National Forest and Rustle Hill Winery.
Opens in a new windowSunset Ridge - Cabin 4
Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Jonesboro
With a stay at this vacation home in Jonesboro, you'll be within a 10-minute drive of Shawnee National Forest and Anna City Park.
Opens in a new windowCharming 2-bedroom with AC, WiFi in lovely Jonesboro
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cape Girardeau Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Cape Girardeau vacation homes are the perfect way for you to wing it.

Holiday houses in Cape Girardeau let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Cape Girardeau in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Cape Girardeau adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Cape Girardeau with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Cape Girardeau vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Cape Girardeau Holiday Homes essential information

Accommodation
64 Holiday Homes
Lowest Price
AU$121
Highest Price
AU$379
Popular accommodation
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen, * On the Wine Trail * Hot Tub * Wi-Fi *, Beautiful location in the secluded woods , * Best Location on the Wine Trail! * Hiking Trail 1 min away * Wi-Fi *, Little Blue Cottage on Spanish, Serenity South -- Gardens, River-Views, and Refreshing Space, Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck, Sunset Ridge - Cabin 4, Charming 2-bedroom with AC, WiFi in lovely Jonesboro

Top trending hotels in Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is AU$155 per night from 5 Oct to 6 Oct
AU$155
5 Oct - 6 Oct
includes taxes & fees
When you stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 10-minute drive ...
Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

2 out of 5
777 Main St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is AU$213 per night from 19 Oct to 20 Oct
AU$213
19 Oct - 20 Oct
includes taxes & fees
When you stay at The Riverview in Cape Girardeau, you'll be in the entertainment district, within a 15-minute walk of Shawnee National Forest and Mississippi ...
Opens in a new windowThe Riverview
Pear Tree Inn Cape Girardeau Near the Medical Center

Pear Tree Inn Cape Girardeau Near the Medical Center

2.5 out of 5
3248 William St, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is AU$121 per night from 5 Oct to 6 Oct
AU$121
5 Oct - 6 Oct
includes taxes & fees
With a stay at Pear Tree Inn Cape Girardeau Near the Medical Center, you'll be centrally located in Cape Girardeau, within a 10-minute drive of Shawnee National ...
Opens in a new windowPear Tree Inn Cape Girardeau Near the Medical Center
Save an average of 15% on thousands of hotels when you're signed in
Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy, Cape Girardeau, MO
Fully refundableReserve now, pay when you stay
The price is AU$121 per night from 2 Oct to 3 Oct
AU$121
2 Oct - 3 Oct
includes taxes & fees
Located in Cape Girardeau, Pear Tree Inn Cape Girardeau West is in a rural location, within a 5-minute drive of Saint Francis Medical Center and Saint Francis ...
Opens in a new windowPear Tree Inn Cape Girardeau West
Don't see what you're looking for?
See all available properties in Cape Girardeau
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Subject to availability and chosen travel dates.