Book Holiday Homes in Cape Girardeau

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Featured Holiday Homes in Cape Girardeau

On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower

On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower

Alto Pass IL
With a stay at this vacation home in Alto Pass, you'll be a 1-minute walk from Shawnee National Forest and 15 minutes by foot from Peachbarn Winery.
Opens in a new windowOn the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower
* On the Wine Trail * Hot Tub * Wi-Fi *

* On the Wine Trail * Hot Tub * Wi-Fi *

Alto Pass IL
With a stay at this vacation home, you'll be centrally located in Alto Pass, steps from Shawnee National Forest and 15 minutes by foot from Peachbarn ...
Opens in a new window* On the Wine Trail * Hot Tub * Wi-Fi *
Notting Hill Cottage

Notting Hill Cottage

Alto Pass IL
With a stay at this vacation home in Alto Pass, you'll be a 1-minute drive from Shawnee National Forest and 6 minutes from Peachbarn Winery.
Opens in a new windowNotting Hill Cottage
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Sip, Hike, Relax - A Private 20-Acre Haven in Wine Country

Sip, Hike, Relax - A Private 20-Acre Haven in Wine Country

2 out of 5
Alto Pass IL
With a stay at this vacation home in Alto Pass, you'll be steps from Shawnee National Forest and a 3-minute drive from Peachbarn Winery.
Opens in a new windowSip, Hike, Relax - A Private 20-Acre Haven in Wine Country
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Anna IL
With a stay at this vacation home, you'll be centrally located in Anna, within a 15-minute drive of Shawnee National Forest and Shawnee Community College.
Opens in a new windowSpacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
Wine Trail, Cozy Cabin plus hot tub

Wine Trail, Cozy Cabin plus hot tub

Cobden IL
With a stay at this vacation home in Cobden, you'll be within a 10-minute drive of Shawnee National Forest and Owl Creek Vineyard.
Opens in a new windowWine Trail, Cozy Cabin plus hot tub
Sunset Ridge - Cabin 4

Sunset Ridge - Cabin 4

Cobden IL
With a stay at this vacation home in Cobden, you'll be steps from Shawnee National Forest and Rustle Hill Winery.
Opens in a new windowSunset Ridge - Cabin 4
Quaint, Beautiful Home next to SEMO and Hospital

Quaint, Beautiful Home next to SEMO and Hospital

Cape Girardeau MO
With a stay at this vacation home in Cape Girardeau, you'll be within a 5-minute drive of Mississippi River and Shawnee National Forest.
Opens in a new windowQuaint, Beautiful Home next to SEMO and Hospital
Beautiful location in the secluded woods

Beautiful location in the secluded woods

Pomona IL
The price is AU$241 per night from 2 Feb to 3 Feb
AU$241
2 Feb - 3 Feb
includes taxes & fees
When you stay at this vacation home in Pomona, you'll be 1 minutes by foot from Shawnee National Forest.
Opens in a new windowBeautiful location in the secluded woods
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cape Girardeau Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Cape Girardeau vacation homes are the perfect way for you to wing it.

Holiday houses in Cape Girardeau let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Cape Girardeau in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Cape Girardeau adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Cape Girardeau with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Cape Girardeau vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Cape Girardeau Holiday Homes essential information

Accommodation
66 Holiday Homes
Lowest Price
AU$136
Highest Price
AU$241
Popular accommodation
On the Wine Trail - Minutes to Giant City, Shawnee Forest, SIU - Amazing Shower, * On the Wine Trail * Hot Tub * Wi-Fi *, Notting Hill Cottage, Sip, Hike, Relax - A Private 20-Acre Haven in Wine Country, Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen, Wine Trail, Cozy Cabin plus hot tub, Sunset Ridge - Cabin 4, Quaint, Beautiful Home next to SEMO and Hospital, Beautiful location in the secluded woods

Top trending hotels in Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is AU$160 per night from 22 Feb to 23 Feb
AU$160
22 Feb - 23 Feb
includes taxes & fees
When you stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 10-minute drive ...
Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is AU$156 per night from 9 Feb to 10 Feb
AU$156
9 Feb - 10 Feb
includes taxes & fees
When you stay at The Riverview in Cape Girardeau, you'll be in the entertainment district, within a 15-minute walk of Mississippi River and Shawnee National ...
Opens in a new windowThe Riverview
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is AU$144 per night from 22 Feb to 23 Feb
AU$144
22 Feb - 23 Feb
includes taxes & fees
With a stay at Drury Inn & Suites Cape Girardeau, you'll be centrally located in Cape Girardeau, within a 10-minute drive of Shawnee National Forest and Mississippi ...
Opens in a new windowDrury Inn & Suites Cape Girardeau
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Candlewood Suites Cape Girardeau by IHG

Candlewood Suites Cape Girardeau by IHG

2.5 out of 5
485 S Mount Auburn Rd Cape Girardeau MO
Fully refundable
The price is AU$136 per night from 22 Feb to 23 Feb
AU$136
22 Feb - 23 Feb
includes taxes & fees
With a stay at Candlewood Suites Cape Girardeau by IHG in Cape Girardeau, you'll be within a 10-minute drive of Shawnee National Forest and Mississippi ...
Opens in a new windowCandlewood Suites Cape Girardeau by IHG
Don't see what you're looking for?
See all available properties in Cape Girardeau
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

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^Subject to availability and chosen travel dates.