Book Holiday Homes in Cape Girardeau

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Featured Holiday Homes in Cape Girardeau

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen

Anna IL
With a stay at this vacation home, you'll be centrally located in Anna, within a 15-minute drive of Shawnee National Forest and Shawnee Community College.
Opens in a new windowSpacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen
Wine Trail, Cozy Cabin plus hot tub

Wine Trail, Cozy Cabin plus hot tub

Cobden IL
With a stay at this vacation home in Cobden, you'll be within a 10-minute drive of Shawnee National Forest and Owl Creek Vineyard.
Opens in a new windowWine Trail, Cozy Cabin plus hot tub
Little Blue Cottage on Spanish

Little Blue Cottage on Spanish

Cape Girardeau MO
The price is AU$156 per night from 22 Mar to 23 Mar
AU$156
22 Mar - 23 Mar
includes taxes & fees
With a stay at this vacation home in Cape Girardeau, you'll be within a 5-minute walk of Mississippi River and Shawnee National Forest.
Opens in a new windowLittle Blue Cottage on Spanish
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Beautiful location in the secluded woods

Beautiful location in the secluded woods

Pomona IL
The price is AU$262 per night from 22 Mar to 23 Mar
AU$262
22 Mar - 23 Mar
includes taxes & fees
When you stay at this vacation home in Pomona, you'll be 1 minutes by foot from Shawnee National Forest.
Opens in a new windowBeautiful location in the secluded woods
Cozy and Updated Farmhouse with King Suite

Cozy and Updated Farmhouse with King Suite

Anna IL
The price is AU$229 per night from 18 Mar to 19 Mar
AU$229
18 Mar - 19 Mar
includes taxes & fees
Located in Anna, this vacation home is in a rural location, a 2-minute drive from Shawnee Community College and 5 minutes from Anna City Park.
Opens in a new windowCozy and Updated Farmhouse with King Suite
“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau

Cape Girardeau MO
With a stay at this vacation home, you'll be centrally located in Cape Girardeau, within a 5-minute drive of Mississippi River and Shawnee National Forest.
Opens in a new window“Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau
Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck

Anna IL
With a stay at this vacation home in Anna, you'll be within a 15-minute drive of Shawnee National Forest and Shawnee Community College.
Opens in a new windowSpacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck
Serenity South -- Gardens, River-Views, and Refreshing Space

Serenity South -- Gardens, River-Views, and Refreshing Space

Cape Girardeau MO
The price is AU$350 per night from 17 Apr to 18 Apr
AU$350
17 Apr - 18 Apr
includes taxes & fees
When you stay at this vacation home in Cape Girardeau, you'll be on a river, just steps from Shawnee National Forest and Mississippi River.
Opens in a new windowSerenity South -- Gardens, River-Views, and Refreshing Space
* On the Wine Trail * Hot Tub * Wi-Fi *

* On the Wine Trail * Hot Tub * Wi-Fi *

Alto Pass IL
With a stay at this vacation home, you'll be centrally located in Alto Pass, steps from Shawnee National Forest and 15 minutes by foot from Peachbarn ...
Opens in a new window* On the Wine Trail * Hot Tub * Wi-Fi *
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

Cape Girardeau Holiday Houses

Do you love last minute road trips and late-night food runs and sunrises on the beach? Do words like “schedule” and “calendar” make you shout, “Don’t box me in!”? You might be a little bit of a rebel. But you’re a rebel with a cause: having a smashing holiday. Itinerary? What’s that? Our Cape Girardeau vacation homes are the perfect way for you to wing it.

Holiday houses in Cape Girardeau let you live life on your own terms. You’ll have so much space, you’ll wish you had more friends and family—but you can always invite over the neighbours. You can often have luxury amenities, but with all the attractions of Cape Girardeau in your backyard, budget holiday homes will do just fine, too. That will just leave you more dough to spend on the important things: cocktails, brunch, and local Cape Girardeau adventures, obvs.

If your adventure buddy happens to have fur and four legs, you just might find a pet-friendly holiday house in Cape Girardeau with your name on it.

No need to spend big bickies for a holiday beach house the size of Buckingham Palace—unless you’re really in trouble with bae. We’ve got a great selection of Cape Girardeau vacation homes with everything you need for a seriously amazing getaway. Throw out that daily planner and hit “reject” on all those meeting invites. You’re off to a place where there are no rules.

Cape Girardeau Holiday Homes essential information

Accommodation
66 Holiday Homes
Lowest Price
AU$115
Highest Price
AU$350
Popular accommodation
Spacious 2 BR, 1 1/2 baths, hot tub, pool table, outside room, full kitchen, Wine Trail, Cozy Cabin plus hot tub, Little Blue Cottage on Spanish, Beautiful location in the secluded woods , Cozy and Updated Farmhouse with King Suite, “Brickyard”-Recently Remodeled Dutch Colonial Revival in Downtown Cape Girardeau, Spacious 3 bedroom, 2 full baths, hot tub, fireplace, full kitchen, outside deck, Serenity South -- Gardens, River-Views, and Refreshing Space, * On the Wine Trail * Hot Tub * Wi-Fi *

Top trending hotels in Cape Girardeau

Drury Plaza Hotel Cape Girardeau Conference Center

Drury Plaza Hotel Cape Girardeau Conference Center

3 out of 5
3351 Percy Drive Cape Girardeau MO
The price is AU$160 per night from 29 Mar to 30 Mar
AU$160
29 Mar - 30 Mar
includes taxes & fees
When you stay at Drury Plaza Hotel Cape Girardeau Conference Center in Cape Girardeau, you'll be connected to the convention center, within a 10-minute drive ...
Opens in a new windowDrury Plaza Hotel Cape Girardeau Conference Center
The Riverview

The Riverview

4 out of 5
777 Main St Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is AU$154 per night from 26 Mar to 27 Mar
AU$154
26 Mar - 27 Mar
includes taxes & fees
When you stay at The Riverview in Cape Girardeau, you'll be in the entertainment district, within a 15-minute walk of Shawnee National Forest and Mississippi ...
Opens in a new windowThe Riverview
Drury Inn & Suites Cape Girardeau

Drury Inn & Suites Cape Girardeau

3 out of 5
3303 Campster Drive Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is AU$144 per night from 23 Mar to 24 Mar
AU$144
23 Mar - 24 Mar
includes taxes & fees
With a stay at Drury Inn & Suites Cape Girardeau, you'll be centrally located in Cape Girardeau, within a 10-minute drive of Shawnee National Forest and Mississippi ...
Opens in a new windowDrury Inn & Suites Cape Girardeau
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Pear Tree Inn Cape Girardeau West

Pear Tree Inn Cape Girardeau West

2.5 out of 5
103 Cape West Pkwy Cape Girardeau MO
Fully refundableReserve now, pay when you stay
The price is AU$115 per night from 29 Mar to 30 Mar
AU$115
29 Mar - 30 Mar
includes taxes & fees
Located in Cape Girardeau, Pear Tree Inn Cape Girardeau West is in a rural location, a 3-minute drive from Saint Francis Medical Center and 5 minutes from Saint ...
Opens in a new windowPear Tree Inn Cape Girardeau West
Don't see what you're looking for?
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Lowest nightly price found within the past 24 hours based on a 1 night stay for 2 adults. Prices and availability subject to change. Additional terms may apply.

**Terms and Conditions apply.
^Subject to availability and chosen travel dates.